LY573636-sodium (tasisulam) is a small molecule antitumor agent with a novel mechanism of action currently being investigated in a variety of human cancers. In vitro, tasisulam induced …

Tasisulam enhances TRAIL-induced apoptosis by activating both extrinsic and intrinsic apoptotic pathways, achieved through upregulation of death receptor 5 (DR5) and downregulation of B …

Tasisulam is a thiophene substituted by a 2,4-dichlorobenzamide -N-sulfonyl and bromo groups at positions 2 and 4, respectively. It induces tumour cell apoptosis via ROS induction and …

This phase I study was carried out to determine the phase II recommended dose of tasisulam sodium (hereafter, tasisulam), a novel anticancer agent with a unique mechanism of action. …

在Calu-6非小细胞肺癌异种移植模型中Tasisulam (25或者50mg/kg，i.v.)表现出剂量依赖性的抗肿瘤活性，诱导细胞凋亡，使与肿瘤相关的血管正常化。 此外，Tasisulam对一系列体内异种移 …

Purpose: To determine the recommended/maximum tolerated dose (MTD), pharmacokinetics (PK), and safety profile of tasisulam sodium (hereafter tasisulam), a novel anticancer agent. …

2016年10月20日 · Get severity rating, description, and management advice. Tasisulam has been used in trials studying the treatment and basic science of Melanoma, Lymphoma, Solid …

Tasisulam is a anticancer agent and induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death. Tasisulam inhibits mitotic …

2011年4月1日 · Tasisulam, a TGF-β/TGF-β type I receptor kinase (ALK5) inhibitor, has been tested in two phase I clinical trials in patients with refractory or malignant solid tumors, …

Tasisulam Sodium is the sodium salt of an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a …