2024年2月15日 · Acute T cell mediated rejection (TCMR): Usually seen during the first month after transplantation or later as immune suppression decreases due to noncompliance, adjustment of medication by physicians (as complications present), gastrointestinal diseases, metabolic diseases, etc.

2024年1月3日 · Late onset TCMR often presents in patients > 1, 3 or 6 months after transplantation; however, it is mostly believed to present after 6 months of transplantation often as a result of noncompliance with immunosuppressive medications. Answer E is incorrect because late onset TCMR has no negative association with age of the recipient.

2024年1月29日 · 2019 Banff classification for antibody mediated rejection (ABMR), borderline changes, T cell mediated rejection (TCMR) and polyomavirus nephropathy (Am J Transplant 2020;20:2318) Category 1: normal biopsy or nonspecific changes Category 2: antibody mediated changes Active ABMR Chronic active ABMR; all 3 criteria must be met for diagnosis

2022年11月8日 · Typical T cell mediated rejection is characterized by (at least 2 out of 3): Mixed portal inflammatory infiltrates: mainly lymphocytes (can appear activated, with larger nuclei and prominent nucleoli) with few eosinophils, plasma cells and possibly neutrophils

Detection of moderate / severe acute TCMR is important because it requires modification in the immunosuppressive regimen and may exacerbate recurrent hepatitis B / recurrent hepatitis C Histologic findings are similar in both conditions: lymphocytes and eosinophils in the portal tracts, bile duct injury, endotheliitis Favoring acute TCMR