2024年12月25日 · THBD (Thrombomodulin) is a Protein Coding gene. Diseases associated with THBD include Thrombophilia Due To Thrombomodulin Defect and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Diseases …

Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS).

2020年10月8日 · THBD (thrombomodulin) is an anticoagulant transmembrane factor expressed in endothelial cells that leads to the conversion of protein C into its activated form. 1 Beyond coagulation, THBD can affect inflammation and barrier function in different pathological diseases and organs. 2 Cell-specific deletion of Thbd in the whole endothelium leads to ...

2023年5月16日 · 该研究确定血栓调节蛋白（thbd）信号传导是衰老细胞命运的关键分子决定因素。 尽管THBD通常仅限于内皮细胞，但在衰老哺乳动物组织和衰老细胞模型中，THBD在衰老程序的所有阶段都会迅速上调并维持。

2024年12月28日 · 本文将详细介绍THBD基因的功能与作用机制，包括其生物学功能、信号通路、与疾病的关系等，帮助读者全面理解这一重要的基因。 THBD基因概述 THBD基因编码的蛋白叫做血栓调节蛋白（thrombomodulin），这种蛋白在血管内皮细胞表面大量表达。

2023年5月11日 · Here, we identify thrombomodulin (THBD) signaling as a key molecular determinant of the senescent cell fate. Although normally restricted to endothelial cells, THBD is...

由这种无内含子基因编码的蛋白质是一种内皮特异性 I 型膜受体，可结合凝血酶。 这种结合导致蛋白 C 的激活，从而降解凝血因子 Va 和 VIIIa 并减少凝血酶的产生量。 该基因的突变是血栓栓塞性疾病的一个原因，也称为遗传性血栓形成倾向。 [RefSeq 提供，2008 年 7 月] The protein encoded by this intronless gene is an endothelial-specific type I …

2025年2月8日 · Title: Novel nucleotide variations in the thrombomodulin (THBD) gene involved in coagulation pathways can increase the risk of recurrent pregnancy loss (RPL). Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality.

Objective: THBD (thrombomodulin) is part of the anticoagulant protein C-system that acts at the endothelium and is involved in anti-inflammatory and barrier-stabilizing processes. A recombinant soluble form of THBD was shown to have protective effects in different organs, but how the endogenous THBD is regulated during ischemia, particularly in ...

2022年1月5日 · 尽管几项研究已经在静脉血栓栓塞 (VTE)患者中发现了血栓调节蛋白基因 (THBD)变异，但THBD在VTE患者中的作用仍有待阐明。 近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，该研究旨在明确大型中老年人群中罕见和常见THBD变异个体的血栓形成风险。 研究人员对参与马尔默饮食与癌症研究 (1991-1996)的28794名受试者（出生于1923-1950年，60%为女性）的THBD外显子组序列进行了合格突变 …