2024年5月29日 · Background: TIPN can impact the ability to complete cancer treatment as well as patient quality of life and functional status. To create a risk prediction model for TIPN, a prospective observational cohort study was conducted.

2025年1月31日 · Purpose: Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting toxicity of paclitaxel in patients with cancer. TIPN prediction is challenging although patients with higher systemic paclitaxel exposure have higher TIPN risk. This study aimed to identify protein predictors of TIPN and paclitaxel pharmacokinetics (PK).

2015年11月15日 · Purpose: Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many cancer patients. Currently, there are no clinically implemented biomarkers to predict which patients might be at increased risk for TIPN. We present a comprehensive approach to identification of genetic variants to predict TIPN.

Taxane-induced peripheral neuropathy (TIPN) is a common toxicity and confers significant morbidity with no validated therapies. Literature detailing TIPN is inconsistent in reporting its frequency, severity, risk factors, impact upon treatment course, and management practices.

Taxane-induced peripheral neuropathy (TIPN) occurs in up to 70% of patients, impacting quality of life both during and after treatment. TIPN typically manifests as tingling and numbness in the hands and feet and can cause irreversible loss of function of peripheral nerves. TIPN can be dose-limiting, potentially impacting clinical outcomes.

虽然紫杉烷有助于改善整体癌症的长期生存率，但它们的毒性，诱导的周围神经病变（tipn），是患者最重要的生存问题之一。 TIPN的症状因人而异，可能是严…

2019年8月29日 · 紫杉类药物引起的周围神经毒性（tipn） 然而，紫杉类药物引起的周围神经毒性（Taxane-induced peripheral neuropathy，TIPN）是剂量限制性毒性，主要表现为肢端麻木、疼痛等感觉异常，甚至运动受限。

2017年2月6日 · tipn的发生可能与沙利度胺抗血管新生作用相关，致使神经纤维缺血、tnfα表达下调、nf–κb通路阻断，进而诱发神经纤维的损伤、促发神经细胞死亡等[]。

Taxane-induced peripheral neuropathy (TIPN) is problematic for several reasons. First, it is a growing issue due to improved long-term cancer survival. More cancer patients live longer or are cured due to the greater effectiveness of new drugs and therapeutic regimes.

2025年1月31日 · Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting toxicity of paclitaxel in patients with cancer. TIPN prediction is challenging although patients with higher systemic paclitaxel exposure have higher TIPN risk. This study aimed to identify protein predictors of TIPN and paclitaxel pharmacokinetics (PK).