Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] . TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6] .

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.

2024年12月25日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

2010年1月19日 · Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Tumour necrosis factor (TNF)- α is a key...

2021年3月8日 · In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases. Keywords: TNF-α; TNF-α inhibitors; autoimmune diseases; inflammatory bowel disease; psoriatic arthritis; rheumatoid arthritis.

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions.

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate apoptosis and regulate cell survival and proliferation.