Anti-U1 RNP antibodies typically appear in both SLE and MCTD. In MCTD, the presence of U1 RNP is required for diagnosis, whereas anti-RNP antibodies occur in only 30-40% of SLE. …

INTRODUCTION Mixed connective tissue disease (MCTD) is a systemic rheumatic disease characterized by the presence of high-titer anti-U1 ribonucleoprotein (RNP) antibodies in …

The U1-RNP antibody test offered by Mayo Clinic detects antibodies to both RNP68 and RNPA proteins. Combined response is more sensitive and less specific than assays to the Sm …

2023年8月29日 · Anti-U1 RNP (Ribonucleoprotein) antibodies are autoantibodies that target a specific cellular component called the U1 small nuclear ribonucleoprotein particle. These …

However, anti-U1 RNP positivity was associated with better survival regardless of sex, age, functional, or hemodynamic parameters in Sobanski’s research [11]. Therefore, there is a …

The U1 small nuclear ribonucleoprotein particle (snRNP) is a target of autoreactive B cells and T cells in several rheumatic diseases including systemic lupus erythematosus (SLE) and mixed …

Anti-U1-RNP positivity remains mandatory for the mixed connective tissue disease (MCTD) diagnosis, reason for which anti-U1-RNP occurrence in patients with lupus clinical features …

2024年9月14日 · Autoimmune diseases can be complex and challenging to diagnose, especially when symptoms overlap across different conditions. One of the critical tools doctors use to …

2023年7月9日 · Mixed connective tissue disease (MCTD) is an autoimmune disorder that involves features of three different autoimmune diseases – systemic lupus erythematosus, …

Systemic sclerosis (SSc) is a generalized connective tissue disease which is characterized by the presence of several autoantibodies. To determine the prevalence and antigen specificity of …