This gene encodes the U2AF large subunit, which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The …

2014年10月19日 · Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to directly define ~88% of functional 3′ splice sites in the human …

含有rs结构域的主要剪接因子包括u2af亚基以及u1 snrnp复合物中u170k蛋白。在含有rs结构域中最常见的是sr家族蛋白，它的n端含有rrm结构域以及在c端含有rs结构域。 在sr家族蛋白中有一 …

U2AF是U2 snRNP auxiliary factor即U2 snRNP辅助因子。 这个蛋白质又叫人类淋巴细胞抗原B相关转录本1蛋白(HLA-B-associated transcript 1 protein, BAT1)，这个蛋白有RNA解旋酶活性；

2024年12月25日 · U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene …

U2 auxiliary factor (U2AF) complex is a non–small nuclear ribonucleoprotein protein required for binding U2 small nuclear ribonucleoprotein to the pre-mRNA branch site and is involved in the …

2020年9月21日 · Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1 complexed with target RNA, revealing the mechanism of 3´ splice site selection, and …

2016年3月8日 · How the essential pre-mRNA splicing factor U2AF 65 recognizes the polypyrimidine (Py) signals of the major class of 3′ splice sites in human gene transcripts …

单个亚基的结合特异性在剪接体组装和功能中起着至关重要的作用。论文第一作者Lena Voithenberg说，“我们研究的被称作U2辅助因子（简写为U2AF）的组装因子在正确识别这些 …

U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the …