2024年12月25日 · UFD1 (Ubiquitin Recognition Factor In ER Associated Degradation 1) is a Protein Coding gene. Diseases associated with UFD1 include Digeorge Syndrome and Velocardiofacial Syndrome. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Cellular responses to stimuli.

2019年12月13日 · Ufd1 occupies a hydrophobic groove of the Mpr1/Pad1 N-terminal (MPN) domain of Npl4, which corresponds to the catalytic groove of the MPN domain of JAB1/MPN/Mov34 metalloenzyme (JAMM)-family...

由该基因编码的蛋白质与其他两种蛋白质形成复合物，即核蛋白定位 4 和含有 valosin 的蛋白质，该复合物是泛素化蛋白质降解所必需的。 此外，该复合物控制有丝分裂纺锤体的分解和有丝分裂后封闭核膜的形成。 该基因的突变与 Catch 22 综合征以及心脏和颅面缺陷有关。 可变剪接导致编码不同异构体的多个转录变体。 已在 18 号染色体上鉴定出一个相关的假基因。 [RefSeq 提供，2009 年 6 月]

2007年8月8日 · Here we show that Ufd1 directly interacts with gp78 and functions as a cofactor. Ufd1 enhances the E3 activity of gp78, accelerates the ubiquitination and degradation of reductase, and eventually promotes receptor-mediated uptake of low-density lipoprotein.

2011年5月31日 · The ubiquitin-recognition protein Ufd1 facilitates clearance of misfolded proteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we report that prolonged ER stress represses Ufd1 expression to trigger cell …

This study identifies Ufd1 as a cofactor of gp78, reveals an unappreciated function of Ufd1 in the ubiquitination reaction during endoplasmic reticulum -associated degradation, and illustrates that Ufd1 plays a critical role in cholesterol metabolism.

泛素一蛋白酶体途径是细胞内蛋白质选择性降解的主要途径,参与多种真核生物细胞生理过程,与细胞的生理功能和病理状态有着密切的关系.该途径中ufd1作为泛素识别因子介导泛素化的靶蛋白&26s蛋白酶体降解.该文在概述泛素一蛋白酶体途径作用机制的基础上,对 ...

Abstract: A fragment of ubiquitin fusion degradation protein (UFD) gene UFD1 was cloned from tomato by reverse transcription‐polymerase chain reaction (RT‐PCR) , and its role in regulation of plant disease and stress resistance was analyzed employing virus‐induced gene silencing (VIGS) technique . The results

Here, we show that MYC transcriptionally upregulates the ubiquitin fusion degradation 1 (UFD1) gene in T-cell acute lymphoblastic leukemia (T-ALL). Allelic loss of ufd1 in zebrafish induces tumor cell apoptosis and impairs MYC-driven T-ALL …

2023年10月4日 · Post-translational ubiquitin-protein conjugates are recognized for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. This family includes UFD1, a 40kD protein that is …