Vav1: a key signal transducer downstream of the TCR - PubMed
Vav1 is a 95-kDa protein expressed in all hemopoietic cells that becomes rapidly tyrosine phosphorylated following T cell antigen receptor (TCR) stimulation. Vav1 contains multiple …
VAV1 Gene - GeneCards | VAV Protein | VAV Antibody
2024年12月25日 · VAV1 (Vav Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with VAV1 include Immunodeficiency 62 and Dyskeratosis Congenita, …
VAV1 as a putative therapeutic target in autoimmune and chronic ...
2024年7月25日 · The guanine nucleotide exchange factor (GEF) VAV1, a previously ‘undruggable’ protein integral to T/B lymphocyte antigen–receptor signaling, promotes actin …
Vav1 Transduces T Cell Receptor Signals to the Activation of ...
Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the thymus. Furthermore, Vav1-deficient thymocytes show greatly …
Vav1 Regulates T-Cell Activation through a Feedback Mechanism …
2015年7月2日 · Vav1, a Rac/Rho guanine nucleotide exchange factor and a critical component of the T-cell receptor (TCR) signaling cascade is tyrosine phosphorylated rapidly in response to T …
Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the …
Many deregulated signal transducer proteins are involved in various cancers at numerous stages of tumor development. One of these, Vav1, is normally expressed exclusively in the …
VAV1 vav guanine nucleotide exchange factor 1 [ (human)]
Vav1 Sustains the In Vitro Differentiation of Normal and Tumor Precursors to Insulin Producing Cells Induced by all-Trans Retinoic Acid (ATRA). Cancer-associated mutations in VAV1 trigger …
Human Vav1 Expression in Hematopoietic and Cancer Cell Lines Is ...
Vav1 is a signal transducer protein that functions as a guanine nucleotide exchange factor for the Rho/Rac GTPases in the hematopoietic system where it is exclusively expressed. Recently, …
VAV1 as a putative therapeutic target in autoimmune and chronic ...
The guanine nucleotide exchange factor (GEF) VAV1, a previously 'undruggable' protein integral to T/B lymphocyte antigen-receptor signaling, promotes actin polymerization, immunological …
VAV1 as a putative therapeutic target in autoimmune and chronic ...
2024年8月1日 · Mammalian dual-function guanine nucleotide exchange factor (GEF) VAV1 regulates T/B cell receptor signaling, T cell activation, T helper cell differentiation, cytokine …
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