纳米抗体（Nanobodies）综述（HCAb,Nb,sdAb,VHH）简介 - 知乎
2023年5月24日 · 尺寸在纳米范围内的重组抗原特异性单结构域VHH也称为纳米抗体（Nb）或单结构域抗体（sdAb）。 在这篇综述中，我们总结了HCAbs和VHH结构域的主要结构特征，并提 …
Single-domain antibody - Wikipedia
A single-domain antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind …
Application Progress of the Single Domain Antibody in Medicine
The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies, sdAb is a …
sdAb单域抗体-VHH纳米抗体-最小的抗体片段-南京铭研生物
单域抗体 (single-domain antibody，SdAb)只包含单一的抗体可变区（VH/VL）。 同常规的抗体一样，它也能够选择性地结合特定抗原。 单域抗体的分子量仅为12-15 kDa，远小于由两条重链 …
Immunological Reviews|纳米抗体在生物医药领域的开发与应用
重链抗体（HCAbs）是一类独特的抗体，不含轻链，仅由两条重链组成。它通过重链抗体可变区（VHH）识别抗原，VHH也称单域抗体（sdAb）或纳米抗体（Nb）。在骆驼科动物的血清 …
Design of single-domain VHH antibodies to increase the binding …
2023年6月30日 · Mutating a residue away from the antigen binding site to lysine increased the binding activity of sdAbs. Single-domain antibodies, or VHH, nanobodies, are attractive tools in …
Single domain antibody: Development and application in
2024年8月21日 · Heavy-chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains-only that recognize their cognate antigen by virtue …
Frontiers | Single-Domain Antibodies and the Promise of Modular ...
2018年2月18日 · Single-domain antibodies (sdAbs), in particular those engineered from the variable heavy-chain fragment (VHH gene) found in Camelidae heavy-chain antibodies (or …
【2.7.1】纳米抗体（nanoantibody,VHH,sdAb） - Sam' Note
纳米抗体(nanobody,Nb)， 即重链单域抗体VHH(variable domain of heavy chain of heavy-chainantibody)——骆驼体内存在着天然缺失轻链的重链抗体(heavy-chain antibody,HCAb)， …
A single-domain antibody library based on a stability ... - Nature
2024年7月31日 · Single-domain antibodies (sdAbs) are the smallest functional antibody format (~ 15 kDa) and represent a viable alternative to IgG in many applications. However, unlike...