2024年12月25日 · WDR1 (WD Repeat Domain 1) is a Protein Coding gene. Diseases associated with WDR1 include Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome and Intellectual Developmental Disorder, Autosomal Dominant 61 .

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. [5] [6] This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein ...

关于 wdr1 Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:10,074,339-10,116,799 (from NCBI) This gene has 31 transcripts (splice variants), 211 orthologues and is associated with 1 phenotype.

2025年2月9日 · Title: WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton. Functions of WDR1 in actin filament dynamics and cytoskeletal regulation in health and disease have been described.

2021年9月30日 · To examine how this electrophile-regulated Wdr1-dependent apoptosis interplays with the classical Keap1/Nrf2/AR axis, we measured AR-levels in cells overexpressing Wdr1 using a standard dual ...

构建 Wdr1 条件性诱导敲除小鼠模型，进而分离小鼠原代主动脉平滑肌细胞，诱导敲除 Wdr1 ，检测平滑肌细胞的形态、增殖和迁移情况。PCR结果显示， Wdr1 f/f ；ERT2Cre小鼠模型构建成功。

2018年6月8日 · WDR1 (WD-repeat domain 1) is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, strongly accelerating ADF/cofilin-mediated actin disassembly. The role of WDR1 in non-small cell lung cancer (NSCLC) progression has been unknown.

The WDR1 gene encodes actin-interacting protein-1 (AIP1), which regulates cofilin (see CFL1, 601442)-mediated actin depolymerization and disassembly (summary by Kuhns et al., 2016).

含 wd 重复序列的蛋白 1 （wdr1） 在肌动蛋白细胞骨架重塑中具有重要作用，这已在多种细胞的胞质分裂和细胞迁移中得到证实。 它通过切割肌动蛋白丝和从细丝中解离肌动蛋白单体来进行肌动蛋白分解。

Located in myelin sheath. Is expressed in several structures, including genitourinary system; heart; pharynx mesenchyme; telencephalon; and trunk mesenchyme. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]