α-Synuclein aggregates amplified from patient-derived Lewy …
2023年10月28日 · Our findings demonstrate conspicuous differences in pathological features induced by hPFF vs. ampLB in the brains of wild-type (WT) mice. We then developed a novel …
Staining of WT mouse brains injected with αsyn fibrils
In mice injected into Str, psyn pathology was widely distributed bilaterally throughout the brain, including Str (0.26 mm anterior to bregma), amygdala (1.58 mm posterior to bregma), SN (2.70...
Viral overexpression of human alpha-synuclein in mouse …
2024年12月1日 · Twenty-one days after infusion of AAV DJ- hSyn1-DIO-hASYN WT into the left substantia nigra of mice expressing Cre in dopamine neurons (DAT Cre mice), we performed …
Distinct biological activity of Lewy body α-Synuclein strain in mice
Our findings demonstrate conspicuous differences in pathological features induced by hPFF vs ampLB in the brains of wild-type (WT) mice. We then developed a novel LBD mouse model …
Pathological alpha-synuclein propagates through neural networks
2014年8月6日 · To investigate where αsyn pathologies develop and how they propagate, we injected recombinant αsyn fibrils into substantia nigra, striatum, or entorhinal cortex of WT …
USP19 deubiquitinase inactivation regulates α-synuclein ... - Nature
2023年11月28日 · We report that USP19 depletion significantly reduces pSyn pathology in a mouse model expressing the human α-syn A53T disease-causing mutation as well as in …
The expression level of alpha-synuclein in different neuronal ...
2020年3月17日 · Here we assess the tropism of the aSyn fibrillar polymorph “Fibrils” for primary striatal (Str), cortical (Cx) and hippocampal (Hip) neurons derived from wild-type (WT) and …
Effects of local reduction of endogenous α-synuclein using …
2024年5月14日 · We used a WT mouse, aSyn PFFs intrastriatal inoculation model to examine the effects of Snca ASO injection timing and locations on the initiation and propagation of …
Pathological α-Synuclein Transmission Initiates Parkinson-like
2012年11月16日 · Here, we found that in wild-type nontransgenic mice, a single intrastriatal inoculation of synthetic α-Syn fibrils led to the cell-to-cell transmission of pathologic α-Syn and …
Relationship between aSyn expression level and pSyn
In transgenic mice that exhibit α-syn overexpression (M20, M83, and A30P), α-syn inclusion formation is also more efficient compared with wild type (WT) mice (Gentzel et al., …