NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene. [5][6][7] This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity.

2024年12月25日 · WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with WWP2 include Spondyloepiphyseal Dysplasia, Nishimura Type and Cowden Syndrome 1. Among its related pathways are PIP3 activates AKT signaling and Signaling by Rho GTPases.

编码的蛋白质包含四个 WW 结构域，可能在多个过程中发挥作用，包括软骨形成和通过与 Smad 蛋白和肿瘤抑制因子 PTEN 的相互作用调节致癌信号通路。 已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 10 号染色体的长臂上。 [RefSeq 提供，2012 年 7 月] This gene encodes a member of the Nedd4 family of E3 Ligases, which play an important role in protein ubiquitination.

2022年11月30日 · Here we focus on WWP2, an E3 ubiquitin ligase that acts as a positive genetic regulator of human and murine cardiac fibrosis, and show that myeloid specific deletion of WWP2 reduces cardiac...

2025年2月9日 · WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway. WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.

2025年1月4日 · WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma.

2024年4月1日 · In this review, we describe the multiple roles of WWP2, an E3 ubiquitin ligase with unique and important functions in regulating a wide range of biological processes, including DNA repair, gene expression, signal transduction, and cell-fate decisions.

WWP2 is an E3 ubiquitin ligase that belongs to the NEDD4-like protein family, which is involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes. We show that WWP2 physically interacts with PTEN and mediates its degradation through a ubiquitylation-dependent pathway.

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors.

WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we reviewed the recent research process about the function of WWP2.