Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. [3][4] This gene encodes a zinc finger -containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [4]

2024年12月25日 · ZFY (Zinc Finger Protein Y-Linked) is a Protein Coding gene. Diseases associated with ZFY include Freemartinism and Campomelic Dysplasia. An important paralog of this gene is ZFX. Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'. ( ZFY_HUMAN,P08048 ) Request up-to-date GeneHancer data Download GeneHancer data sheet.

2015年12月16日 · In 1987, the geneticist David Page and his associates 2 identified the first coding gene on the human Y, called ZFY. The gene looked like a winning candidate: it was in the right place; it was...

2025年2月8日 · Studies identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain. Title: Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. NEW Try the new Transcript table.

Studies identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain. This gene encodes a zinc finger-containing protein that may function as a transcription factor.

2016年9月14日 · Gene target information for ZFY - zinc finger protein Y-linked (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Broad expression in testis (RPKM 3.4), prostate (RPKM 3.2) and 20 other tissues. 该基因编码一种含锌指蛋白，可作为转录因子发挥作用。 该基因曾是睾丸决定因子 (TDF) 的候选基因，被错误地称为 TDF。 [RefSeq 提供，2008 年 7 月] This gene encodes a zinc finger-containing protein that may function as a transcription factor.

Zfy被称为Y染色体相关的锌指蛋白转录因子 (Y chromosome linked Zinc-finger protein transcriptional factor),是位于Y染色体短臂上的能够编码锌指蛋白的基因.其基因家族还包括位于X染色体上的Zfx和位于常染色体上的Zfa.该基因家族对DNA、RNA起特异性的转录调控作用,因此Zfy基因被应用于哺乳动物的性别鉴定.最近深入的研究表明,Zfy基因参与哺乳动物的单倍体生精细胞的更新分化和发育,对于减数分裂和精子生成至关重要,这为特异性干扰或控制单一的X或Y精子,从而 …

ZFY has 2,037 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …

ZFY的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为此基因编码一种含锌指蛋白可能作为转录因子发挥作用。 该基因曾经是睾丸决定因子（TDF）的候选基因，被误称为TDF。 [由RefSeq的，2008年7月提供]

对ChinaHolstein及Japaneseblack间的ZFY、ZFX对比分析表明:同种属内不同品种间的SNP也存在差异,但同源性高于种间。 同种属或品种内ZFY与ZFX的同源比较ZFY的SNP高于ZFX,ZFY在进化过程中较ZFX更活跃,而ZFX较为保守,该结果与国外多数学者的研究结果一致犤2、3、13犦,对ZFY与ZFX的SNP性质进行研究发现ZFY中的碱基颠换率为16.22%、ZFX为16%.本文结果可作为奶牛胚胎早期性别鉴定的基础方法。

For several years, ZFY (zinc finger gene on the Y chromosome) was considered the best candidate for the human testis-determining gene TDF. This gene and its close relatives have been intensely studied in the hope of understanding the molecular biology of sex determination, particularly in humans and mice.

1991年4月1日 · For several years, ZFY (zinc finger gene on the Y chromosome) was considered the best candidate for the human testis-determining gene TDF. This gene and its close relatives have been intensely studied in the hope of understanding the molecular biology of sex determination, particularly in humans and mice.

In humans, there is a single widely transcribed ZFY gene, and there is no evidence for a specific role in the testis. Here, we characterize ZFY transcription during spermatogenesis in mice and humans.

该研究首次描述了 Zfy 基因完全缺失的小鼠的详细表型特征。 它提供的证据表明，至少一种 Zfy 同源物的存在对于男性生育能力和在无辅助受精中发挥正常精子功能的发育至关重要。 数据还表明，虽然 Zfy1 的缺失是良性的，但 Zfy2 的缺失对精子发生有轻微的损害。 Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and …

2023年7月31日 · Based on protein structure and in vitro assays, Zfy is expected to drive spermatogenesis as a transcriptional regulator. The combined evidence documents that the presence of at least one Zfy homologue is required for male fertility and that Zfy2 plays a …

1997年4月1日 · 我们得出的结论是，Zfy1和Zfy2确实是ZFY家族的成员，该家族已经从单个共同祖先基因进化而来。 Zfy1和Zfy2是小鼠Y染色体上的同源锌指基因。 为了询问这些基因是否正确地归类为ZFY家族的成员，我们已经对它们的基因组组织与小鼠Zfx，人ZFX和人ZFY的基因组组织进行了表征和比较。 我们显示Zfy1具有11个外显子，分布在至少56 kb，而Zfy2具有9个外显子，分布在至少52 kb。 Zfy2基因座包含大小和序列与Zfy1的所有11个外显子相似的区域，另外还有一 …

2012年3月9日 · In humans, we have identified a major testis-specific ZFY transcript that encodes a protein with the same short acidic domain. This represents the first evidence that ZFY has a conserved function during human spermatogenesis.

Role in the organism: Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. This gene encodes a zinc finger-containing protein that may function as a transcription factor.

2023年6月24日 · Here, we present the story of one mouse Y chromosome gene: zinc finger Y chromosome encoded (Zfy), which was once the center of attention as a potential candidate for the testis-determining factor.