锌指结构域 (Zinc Finger, ZnF)是一种相对较小的蛋白质基序，它包含多个指状突起，可与靶分子串联接触。 其中一些区域与锌结合，但也有许多不结合，而是与铁等其他金属结合，或者根本不与金属结合。 例如，一些家庭成员形成盐桥来稳定手指状褶皱。 它们最初被识别为非洲爪蟾 (Xenopus laevis)转录因子TFIIIA中的DNA结合基序，但现在发现它们可以结合DNA、RNA、蛋白质或脂质底物。 它们的结合特性取决于手指结构域的氨基酸序列、手指间的连接子以及手指的高阶结构 …

Proteins that contain zinc fingers (zinc finger proteins) are classified into several different structural families. Unlike many other clearly defined supersecondary structures such as Greek keys or β hairpins, there are a number of types of zinc fingers, each with a unique three-dimensional architecture.

2024年7月25日 · In this review, we highlight the major classes and observed biological functions of ZNF proteins in mammalian cells. We briefly introduce well-known and newly discovered ZNFs and describe their molecular roles and contributions to human …

2017年11月13日 · ZNFs have key role in development and differentiation of several tissues. ZNFs are involved in tumorigenesis, cancer progression and metastasis formation. Alterations in ZNFs are involved...

研究发现,锌指蛋白在肺癌中发挥着类似于原癌和抑癌基因的功能,是一种潜在的肿瘤基因治疗靶点。 由于小细胞肺癌的发生发展机制复杂,至今尚未完全揭示。 锌指蛋白已被证明在包括非小细胞肺癌在内的许多癌症中起着关键作用。 本文就锌指蛋白与非小细胞肺癌的关系做一综述。 我们将讨论锌指蛋白的组成和类型及其在非小细胞肺癌中的作用机制。 Lung cancer is a kind of malignant tumor that seriously endangers human health, and the molecu-lar mechanisms have not been …

2024年7月24日 · In this review, we highlight the major classes and observed biological functions of ZNF proteins in mammalian cells. We briefly introduce well-known and newly discovered ZNFs and describe their molecular roles and contributions to human …

2021年4月1日 · Stitching of Zn3 (OH)2V2O7•2H2O 2D Nanosheets by 1D Carbon Nanotubes Boosts Ultrahigh-Rate for Wearable Quasi-Solid-State Zn-Ion Batteries.

2021年11月12日 · Here we show that ZNF384, a member of the C2H2 family of ZnF proteins, binds DNA ends in vitro and is recruited to DSBs in vivo. ZNF384 recruitment requires the poly (ADP-ribosyl) polymerase 1...

2021年11月18日 · It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many ZNF are associated with neurological diseases.

2021年8月1日 · Silver-zinc (Ag–Zn) battery are one of the promising aqueous zinc-based battery with non-toxic environment, stable output voltage and high energy density. Flexible electrode plays a key role in excellent mechanical and electrochemical properties of batteries.