2024年6月1日 · Typical bHLHs comprise a highly conserved bHLH domain of ∼60 amino acids, which has two functionally distinct regions: a basic region (b) at the N-terminal side and a HLH region at the C-terminal side [4].The basic region is composed of 13–17 amino acids (with a high proportion of basic amino acids, such as arginine and lysine) and is involved in binding to DNA …

Functional classification of basic helix-loop-helix (bHLH) transcription factors in rice. bHLH genes are involved in various physiological processes for growth, metabolism, signaling, and adaptation to environmental stress.. The members of the same subfamily always have similar functions.

The structure of the bHLH transcription factor complex involved in binding to the E-box sequences of the DNA. We focus on the class II bHLH transcription factors that are expressed and involved in the development of the nervous system.

2023年2月15日 · Murre et al. (1989) first discovered the helix-loop-helix (HLH) structure of TFs E12 and E47 in mice. In the same year, bHLH TFs were first identified in maize (Zea mays L.) (Ludwig et al., 1989).Subsequently, the three-dimensional structure of the complex of the Max protein binding DNA bHLH domain was identified by X-ray diffraction, and it was discovered …

2023年7月5日 · The basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs known as E-boxes (CANNTG) and includes 108 members1. Here we investigate how chromatinized E-boxes are ...

The basic/helix-loop-helix (bHLH) transcription factors and their homologs form a large family in plant and animal genomes. They are known to play important roles in the specification of tissue types in animals. On the other hand, few plant bHLH proteins have been studied functionally. Recent comple …

2004年5月6日 · One basis for the evolutionary classification shown in Table 1 is the presence or absence of additional domains, of which the most common are the PAS, orange and leucine-zipper domains. PAS domains, located carboxy-terminal to the bHLH region, are 260-310 residues long and function as dimerization motifs [].They allow binding with other PAS …

2020年8月13日 · Evolutionary tree analysis of bHLH gene family. To classify the G. biloba bHLH protein subfamilies and identify the evolutionary relationships among the bHLH proteins from G. biloba, Manus ...

2021年7月1日 · The basic helix-loop-helix (bHLH) transcription factor family is one of the largest transcription factor gene families in Arabidopsis thaliana, and contains a bHLH motif that is highly conserved throughout eukaryotic organisms. Members of this family have two conserved motifs, a basic DNA binding re …

2021年6月18日 · Basic helix-loop-helix proteins (bHLHs) comprise one of the largest families of transcription factors in plants. They have been shown to be involved in responses to various abiotic stresses, such as drought, salinity, chilling, heavy metal toxicity, iron deficiency, and osmotic damages. By specifica …