SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling
2022年1月24日 · Mechanistically, NSP5 suppressed avSG formation and disrupted RIG-I–MAVS complex to attenuate the RIG-I–mediated antiviral immunity. In contrast to the multiple targets …
Nonstructural protein 5 – 3C-like proteinase - ORNL
The nonstructural protein 5 (nsp5, also known as 3CLpro), is the main protease of the coronavirus genome, exhibiting as main known role the cleavage of the polyproteins translated from the …
SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and
2022年4月27日 · Previous studies have shown that the nonstructural protein 5 (nsp5, also called 3C-like protease) of alpha- and deltacoronaviruses cleaves Q231 of the NF-κB essential …
Targeting novel structural and functional features of …
Coronavirus protease nsp5 (M pro, 3CL pro) remains a primary target for coronavirus therapeutics due to its indispensable and conserved role in the proteolytic processing of the viral replicase …
Predicted coronavirus Nsp5 protease cleavage sites in the human ...
2022年4月4日 · Nsp5 from the recently emerged SARS-CoV-2 virus interacts with and can cleave human proteins, which may be relevant to the pathogenesis of COVID-19. Based on the …
Main protease of SARS-CoV-2 serves as a bifunctional molecule in ...
2020年10月6日 · We next ectopically expressed different SARS-CoV-2 proteins to study their roles in type I IFN signaling. Among them, SARS-CoV-2 main protease (M pro, also called …
SARS-CoV-2 nsp5 Exhibits Stronger Catalytic Activity and …
2022年4月7日 · Previous studies have shown that the nonstructural protein 5 (nsp5, also called 3C-like protease) of alpha- and deltacoronaviruses cleaves Q231 of the NF-κB essential …
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms …
2021年9月21日 · The innate immune defense is a physical barrier that restricts viral replication. We report here that the SARS-CoV-2 Nsp5 main protease targets RIG-I and mitochondrial …
Predicted coronavirus Nsp5 protease cleavage sites in the human ...
2022年4月4日 · The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several …
The main protease of SARS-CoV-2 downregulates innate immunity …
2023年4月13日 · We found that NSP5, the main protease of SARS-CoV-2, is among the five viral proteins (NSP1, 3, 5, ORF6, and 8) that significantly repressed MAVS-IFN (Supplementary …