2023年1月1日 · The cellular response to the adrenal steroid aldosterone is mediated by the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of ligand-dependent transcription factors. The MR binds more than one physiological ligand with binding at the MR determined by pre-receptor metabolism of glucocorticoid ligands by 11β ...

Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption.

The cellular response to aldosterone is mediated by the mineralocorticoid receptor (MR). This response is best characterized in the renal epithelia with control of sodium and water homeostasis.

2023年9月14日 · Aldosterone helps control water and salt balance; production is controlled by the renin angiotensin aldosterone system (RAAS), adrenocorticotropic hormone (ACTH) and extracellular potassium concentration

Aldosterone production is initiated by angiotensin II stimulation and activation of intracellular Ca (2+) signaling. In aldosterone-producing adenoma (APA) cells, the activation of...

2022年10月16日 · The aldosterone system is diagrammed in Fig. 12.1. This is a closed-loop system consisting of four major components—the paraventricular nucleus of the hypothalamus, the anterior pituitary gland, the adrenal cortex, and the kidneys.

Aldosterone receptor antagonist acts on distal part of distal tubule and collecting tubules. 53,69 They bind to Mrs (Flow diagram 16.5) and prevent mRNA synthesis followed by AIPs expressions. Thus activation of sodium channel is inhibited.

The pleiotropic action of aldosterone in epithelia is mediated by transcription and post-transcription mechanisms, primarily mediated by the intracellular mineralocorticoid receptor (MR), specifically referred to as classical aldosterone receptor.

Aldosterone regulates sodium excretion through mineralocorticoid receptor (MR)-dependent genomic effects in the distal nephron of the kidney. Aldosterone binds to the inactive cytosolic MR of...

2019年7月9日 · Aldosterone acts on ENaC via its receptor MR to produce rapid (non-genomic) effects on intermediate cell signaling molecules (protein kinases, MAP kinases, SGK, Ca 2+, pH, etc.) to enhance ENaC membrane trafficking, channel activity, and stability followed by a latent (genomic) phase to increase the expression of ENaC channel subunits and furthe...