Brucine is an alkaloid closely related to strychnine, most commonly found in the Strychnos nux-vomica tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine.

Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Nux-vomica. Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, ...

2009年4月8日 · Brucine | C23H26N2O4 | CID 442021 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2023年11月1日 · Brucine is a vomiting inducing agent and used in many poison withdrawing cases by inducing vomiting. Brucine has potent anti-inflammatory and analgesic activity. It also possesses anti-cancer activity against many cell lines of cancers. Some of the activities of brucine are discussed below.

Brucine and their nitrogen are the main constituents of Nux-vomica. Brucine is usually used as an anti-inflammatory and analgesic drug to relieve arthritis and traumatic pain.

2020年4月3日 · Brucine is a traditional medicinal herb extracted from seeds of Strychnos nux-vomica L. (Loganiaceae) exhibiting antitumor activity in a variety of cancer models.

Brucine is a bitter-tasting alkaloid extracted from the seeds of S. nux-vomica. It is used for the chiral resolution of optically active carboxylic acids and is isostructural to strychnine with methoxy groups at specific positions of the aromatic ring.

2021年12月22日 · Brucine, one of the main bioactive alkaloids from these seeds, possesses remarkable pharmacological effects such as an anti-inflammatory and antitumor agent. Nevertheless, toxicity limits the clinical application of brucine. Brucine is associated with systemic toxicity such as hepatotoxicity, neurotoxicity, and nephrotoxicity.

2018年11月20日 · Brucine is the main active ingredient in Strychnos and plays an important role in treating diseases. However, brucine is also a toxic ingredient, which limits the scope of its clinical application. Further studies of its pharmacological effects and toxicity will improve its clinical application.

Brucine is an alkaloid from nux vomica, has been shown various pharmacological actions. To study the possible anti-cancer mechanisms on LoVo cells, effects of Brucine on cell viability, cell cycle and apoptosis were investigated.