In molecular biology, an oscillating gene is a gene that is expressed in a rhythmic pattern or in periodic cycles. [1] [2] Oscillating genes are usually circadian and can be identified by periodic changes in the state of an organism. Circadian rhythms, controlled by oscillating genes, have a period of approximately 24 hours. For example, plant ...

2008年10月29日 · Here we describe an engineered genetic oscillator in Escherichia coli that is fast, robust and persistent, with tunable oscillatory periods as fast as 13 min. The oscillator was designed using a...

One of the most compelling reasons to construct synthetic gene oscillators is that they provide a simple, yet highly dynamic, genetic regulatory process and thus provide more data than do circuits exhibiting only steady-state behavior.

'Gene oscillation' refers to the rhythmic fluctuations in the activity or expression of genes over a period of time, as observed in the regulation of clock genes by circadian rhythms in cytosolic Ca2+ levels.

2016年10月12日 · Here we revisit the first synthetic genetic oscillator, the repressilator 1, and modify it using principles from stochastic chemistry in single cells. Specifically, we sought to reduce error...

2008年10月30日 · We consider specific examples of oscillatory processes and discuss four general requirements for biochemical oscillations: negative feedback, time delay, sufficient 'nonlinearity' of the reaction...

2012年3月1日 · In this review, we examine, in detail, how mathematical models of synthetic gene oscillators are derived and the biological processes that affect the dynamics of gene regulation.

2016年1月11日 · Oscillatory gene expression can be generated by transcriptional/translational feedback loops, usually referred to as a genetic oscillator. In this review article, we discuss genetic oscillators in the presence of developmental processes such as cell division, cell movement and cell differentiation.

2015年12月22日 · Synthetic gene oscillators are small, engineered genetic circuits that produce periodic variations in target protein expression. Like other gene circuits, synthetic gene oscillators are noisy and exhibit fluctuations in amplitude and period.

2016年10月10日 · Here we revisited the first synthetic genetic oscillator, the repressilator 1, and modified it based on principles from stochastic chemistry in single cells. Specifically, we sought to reduce error propagation and information losses, not by adding control loops, but by simply removing existing features.