Adiponectin (APN), an adipose-derived adipokine, offers cardioprotective effects although the precise mechanism of action remains unclear. This study was designed to examine the role of APN in high fat diet-induced obesity and cardiac pathology. Adult C57BL/6 wild-type and APN knockout mice were fed a low or high fat diet for 22weeks.

2013年8月1日 · High fat diet intake significantly reduced peak shortening (PS) and maximal velocity of shortening/relengthening (± dL/dt) as well as prolonged time-to-90% relengthening (TR 90) without affecting time-to-PS (TPS) in cardiomyocytes from WT mice.

The HF diet led to decreased insulin sensitivity accompanied by impaired activity of adiponectin-related enzymes in skeletal muscles but not in the liver. These results suggest that the HF diet has a tissue-specific effect on adiponectin and associated enzyme expression.

2020年12月22日 · Two weeks of globular adiponectin (gAcrp30) treatment reduced fasting plasma glucose, triglyceride (TAG), and insulin concentrations and reversed whole-body insulin resistance, which could be attributed to both improved insulin-mediated suppression of endogenous glucose production and increased insulin-stimulated glucose uptake in …

A randomized case-control study by Song et al. showed a significant reduction in adiponectin concentrations by 9.4% in a group of persons following a low-fat high-carbohydrate diet compared to those whose diets included the standard content of those macronutrients.

Recombinant adiponectin supplementation has been tested in different animal studies. Liu et al. analyzed adiponectin administration in adiponectin knockout mice after high-fat diet feeding and found amelioration in metabolic profile (glucose handling, insulin signaling, triglycerides levels, and mitochondrial structure and function) .

2013年2月14日 · We provide here a detailed and comprehensive analysis of skeletal muscle metabolomic profiles in response to adiponectin in adiponectin knockout (AdKO) mice after high-fat–diet (HFD) feeding. Hyperinsulinemic-euglycemic clamp studies showed that adiponectin administration corrected HFD-induced defects in post/basal insulin stimulated R d and ...

2012年9月10日 · Based on these data, we conclude that adiponectin gene therapy ameliorates the metabolic abnormalities caused by feeding mice a HFHS diet and may be a potential therapeutic strategy to improve...

Adiponectin homolog osmotin activates AdipoR1/R2 to suppress abdominal fat accumulation in mice on high-fat diet (HFD) [44, 45], and prevents obesity-caused NAFLD by upregulating AdipoRs/APPL1/PPAR-α/AMPK/SIRT1 pathway .

2017年4月7日 · Recent data indicate that the high-molecular weight (HMW) complexes have the predominant action in metabolic tissues. Studies have shown that adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight.