2024年8月24日 · The coenzyme pyridoxal phosphate (commonly abbreviated PLP) is the active form of vitamin \(B_6\), or pyridoxine. PLP is required for over 100 different reactions in human metabolism, primarily in the various amino acid biosynthetic and degradation pathways.

Pyridoxal phosphate (PLP, pyridoxal 5'- phosphate, P5P), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. [5] .

Pyridoxal phosphate is the coenzyme of amino acid metabolism. In some of its reactions which are transaminations it acts as an amino carrier. Pyridoxal phosphate is an excellent example of a single coenzyme capable of catalyzing completely different reactions (see Scheme 1.21).

2024年8月1日 · Pyridoxal-5′-phosphate (PLP) is arguably the most versatile enzymatic cofactor catalyzing transamination, decarboxylation, epimerization, retro-aldol chemistry, Claisen condensation, and a host of β- and γ-elimination/substitution reactions alongside O 2-dependent monooxygenation and oxidase reactions [1, 2, 3]. It achieves this reaction ...

Two more reaction types in the PLP toolbox are beta-eliminations and beta-substitutions. Serine dehydratase catalyzes a beta-elimination of the hydroxyl group of serine, leading eventually to pyruvate.

Pyridoxal phosphate (PLP) enzymes catalyze many different reaction types on amine and amino acid substrates. [1, 2] The first and common step in all pyridoxal phosphate catalyzed reactions is the formation of an external aldimine intermediate with the substrate.

Pyridoxal 5′-phosphate (PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature.

1984年1月1日 · This chapter discusses the mechanism and stereochemistry of pyridoxal phosphate-dependent enzymic reactions. Pyridoxal phosphate and pyridoxamine phosphate participate in a multiplicity of different biological processes, most noteworthy among these being the reaction involved in the metabolism of amino acids.

They catalyze a wide variety of reactions including racemization, transamination, decarboxylation, elimination, retro-aldol cleavage, Claisen condensation, and others on substrates containing an amino group, most commonly α-amino acids.

2020年3月6日 · Pyridoxal 5′-phosphate (PLP) is a versatile organic cofactor widely employed in metabolism. The cofactor is the active form of vitamin B 6, and it enables reactions with amino acid, oxoacid, or amine substrates. The structure of PLP dictates several features about how it is used in enzymes.