Translesion DNA Synthesis in Human Cells - Sites at Penn State
DNA translesion synthesis (TLS) is a DNA damage tolerance pathway that allows the cell to overcome replication barriers. In TLS, specialized low-fidelity polymerases utilize the damaged …
Translesion Synthesis: Insights into the Selection and ...
An accepted model of translesion synthesis involves DNA polymerase switching steps between a replicative DNA polymerase and one or more TLS DNA polymerases. The mechanisms that …
Translesion DNA Synthesis - PubMed
In these situations, cells are forced to choose between recombination-mediated "damage avoidance" pathways or a specialized DNA polymerase (pol) to traverse the blocking lesion. …
Translesion DNA Polymerases - PMC
To avoid the deleterious consequence of a stalled replication fork, cells use specialized polymerases to traverse the damage. This process, termed “translesion DNA synthesis” (TLS), …
Freedom to err: The expanding cellular functions of ...
2023年10月19日 · Translesion synthesis (TLS) polymerases are best known for acting in the replicative bypass of damaged DNA. However, new evidence has significantly broadened the …
Translesion DNA Synthesis and Mutagenesis in Eukaryotes
Direct replication of DNA damage is termed translesion synthesis (TLS), a mechanism conserved from bacteria to mammals and executed by an array of specialized DNA polymerases.
The identification of translesion DNA synthesis regulators ...
The basics of translesion DNA synthesis. To promote damaged-DNA replication, TLS relies on the Y-family of DNA polymerases (Polη, Polι, Polκ and Rev1) and on the B-family member, Polζ. …
Translesion DNA synthesis and mutagenesis in eukaryotes
2013年3月1日 · Direct replication of DNA damage is termed translesion synthesis (TLS), a mechanism conserved from bacteria to mammals and executed by an array of specialized …