Chronic GVHD most often affects the skin, nails, hair and sweat glands. Symptoms may include: dry, itchy rash; a burning sensation when exposed to sun or heat; a tightening or pulling sensation; a change in skin color; thickening of the skin that can restrict joint movement; taut skin; thin skin that tears easily; scarring; swelling; GVHD may ...

2016年12月2日 · Results:Masson's trichrome staining of the skin sections demonstrated skin thickening with massive fibrosis of the dermis 42 days after BMT. Quantitative collagen assay confirmed collagen volume was significantly increased in the skin of allogeneic recipients compared to syngeneic controls.

2019年1月24日 · Skin was harvested 42 days after BMT or 14 days after intradermal bleomycin treatment. The skin infiltrating cells 14 days after BMT were T cell-separated with anti-Thy1.2 microbeads...

A quality improvement project by staff nurses titled “Skin Rounds” was developed in a hospital BMT unit. This project enhanced staff awareness of skin care and led to early identification and treatment of skin issues while simultaneously increasing patient satisfaction.

2015年11月23日 · In GHVD skin, vacuolization (black arrows) of the epidermis (E) and infiltration (I) of immune cells occurred, whereas control skin showed normal skin structure with sebaceous glands (SGs ...

BMT contributes significantly to tissue repair and regeneration of soft tissue, bacteria suppression, skin repair, and endogenous repairing potential. Bioactive molecules are stable and safe, and their capability of modulating host tissue responses …

2015年2月2日 · Recent studies have demonstrated that allogeneic bone marrow transplantation (BMT) ameliorates the skin blistering phenotype of RDEB patients by restoring Col7. However, the exact therapeutic mechanism of BMT in RDEB remains unclear.

Chronic graft-versus-host disease (GVHD) can affect the skin and underlying tissue. It can also affect the mouth and genitals. Therapies vary depending on the type of skin GVHD a patient is experiencing. People with skin GVHD need to be cautious in the sun and monitor themselves closely for signs of skin cancer.

The purpose of the project was to increase the BMT nurses knowledge and comfort of skin and wound care issues commonly found on a BMT unit. A special emphasis was placed on pressure ulcers and incontinence associated dermatitis.

异基因造血干细胞移植（allo-HSCT）是急性白血病患者的潜在治愈性手段，由于供者可及性高、复发率低且总生存期不劣于HLA全相合同胞供者移植，单倍体相合造血干细胞移植（haplo-SCT）的数量逐年走高，在2022年占国内allo-HSCT的65%。 使用ATG作为非体外去T细胞的“北京方案”是常用预处理方案，但其与感染性并发症的高发有关，可能导致非复发死亡率（NRM）增加，因此许多中心都探索减少ATG的剂量，但ATG的最佳剂量仍然难以确定。