2020年6月26日 · DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis.

DNA甲基化是在DNA甲基转移酶（DNA methyltransferase， DNMTs ）的催化下进行的。该反应以S-腺苷甲硫氨酸（SAM）为甲基供体将胞嘧啶核苷酸第5位碳原子进行甲基化生成5-mC：

2025年1月10日 · Recent sequencing efforts of acute myeloid leukemia (AML) genomes and exomes have identified DNMT3A as one of the most recurrently mutated epigenetic modifiers whose mutation is associated with...

GSK3685032 是一种强效的 DNMT1 选择性抑制剂，通过晶体学研究表明，它与DNMT1的活性位环竞争，以渗透到两个 CpG碱基对 之间的半甲基化DNA。 在体外诱导强有力的DNA甲基化丧失、转录激活和癌细胞生长抑制。 2021年9月27日，美国葛兰素史克的Michael T. McCabe博士等人在《Nature Cancer》上发表了一篇“Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia”的文章。 DNA甲基化是一种 …

2023年11月11日 · This study aimed to investigate the biological function and mechanism of SOCS3 methylation mediated by DNMTs in the development of AML. Methods: Bone marrow samples were collected from 70 AML patients and 20 healthy volunteers. The expression and methylation status of each gene were detected by RT-qPCR, western blot …

2024年9月1日 · Notably, in the acute myeloid leukemia (AML) model, a non-nucleoside DNMT1-specific inhibitor has demonstrated lower toxicity, better tolerability and more favorable pharmacokinetics compared to the conventional nucleoside drug decitabine [17].

2022年7月15日 · Shinichi Mizuno et al. analysed DNMTs expression levels of 33 AML cases by competitive PCR and found that DNMT1 was expressed at a high level in most AML cases. Overexpression of DNMT1 could be associated with the development and relapse of AML triggered by hypermethylation of tumour suppressor genes [ Citation 61 ].

2019年5月8日 · DNMTs are frequently implicated in the pathogenesis and aggressiveness of acute myeloid leukaemia (AML) patients. In this review, we describe and discuss the oncogenic roles of DNMT1, DNMT3A, and DNMT3B in AML.

近期，欧洲血液学杂志发表了一篇名为“dnmts介导的socs3甲基化促进aml的发生和发展”的论文，研究了socs3基因在白血病中的作用及其甲基化机制。 这项研究为白血病的治疗提供了新的思路。

SOCS3 methylation mediated by DNMTs promotes the occurrence and development of AML and can be used as a potential biomarker for the diagnosis and efficacy evaluation of AML.