2023年12月26日 · We found that the mitochondria-specific CoQ potently inhibited GPX4 inhibition–mediated ferroptosis, suggesting that mitochondrial lipid redox regulates ferroptosis in AML cells. Consistently,...

2022年11月15日 · We here study targeting ferroptosis pathway in AML and its mitochondrial (mito-) regulation to develop mechanism-based combination with mito-targeting agents. Results: We first analyzed DepMap datasets to determine the essentiality of ferroptosis-regulating genes in cancer cell lines.

2022年10月1日 · As a potentially AML-specific mechanism that is unusual in solid tumor models, we found that GPX4 inhibition-induced ferroptosis was efficiently blocked by the mitochondria-targeted ubiquinone MitoQ in AML cells.

2023年4月15日 · MitoQ, an analog of coenzyme Q10, is targeted towards mitochondria and acts as a potent antioxidant. This study aimed to explore the effect of MitoQ on APAP-induced liver injury and its possible mechanisms. To investigate this, CD …

Mitoquinone mesylate (MitoQ) is a synthetic analogue of coenzyme Q10 which has antioxidant effects. It was first developed in New Zealand in the late 1990s. [1]

因此本研究拟评估线粒体活性氧（mitochondrialROS，mtROS）在APAP诱导肝细胞铁死亡中的作用，观察线粒体靶向抗氧化剂MitoQ对APAP诱导肝细胞铁死亡的保护作用。 研究方法： 一、动物实验：实验1：为建立APAP诱导的急性肝损伤模型：40只ICR雄性小鼠统一禁食后腹腔注射APAP (300mg/kg)，分别在不同的时点（2、6、24h）取材，检测肝组织GSH、MDA及4-HNE水平，检测肝组织铁死亡特异性标记物ACSL4蛋白及ptgs2mRNA水平，TUNEL法检测肝细胞死亡，透射 …

2022年7月1日 · MitoQ demonstrated these promising effects by inhibiting the activation of the NLRP3 inflammasome, blocking mtROS, and upregulating the expression of M2 markers in FeCl2-treated microglia, promoting the shift of microglia from the M1 to the M2 phenotype [85].

ClpP-mediated degradation of mitochondrial respiratory complex proteins 6 sensitizes AML cells to ferroptosis. GPX4 is a potential therapeutic target in AML with prognostic relevance. TP53 modulations in MOLM13 (CRISPR-mediated gene editing) or Kasumi-1 (knockdown of mutant p53) do not change the ML210 sensitivity

2025年1月15日 · Meanwhile, pharmacological administration of glutathione (GSH), N-acetylcysteine (NAC), and mitoquinone (MitoQ), or genetic overexpression of TRX1 or TERT in MDS and cells could dampen the toxicity caused by thiotert.

MitoQ, an analog of coenzyme Q10, is targeted towards mitochondria and acts as a potent antioxidant. This study aimed to explore the effect of MitoQ on APAP-induced liver injury and its...