Two human hepatocellular carcinoma lines that support HEV replication (Huh7 and the derivative cell line Huh7.5, which contain a RIG-I mutation and support enhanced replication of viruses …

Y1KI affects HEV’s early onset of infection independently of ORF3. (A) HEV replication levels in HEV p6 SGR system in HepG2/C3A cells under treatment of 1 µM Y1KI or 50 µM Rbv at the …

To elucidate the effects of Cyps on HEV genome replication we employed an HEV SGR, a self-replicating RNA in which a portion of the coding sequence for the viral structural proteins is...

Hepatitis E virus (HEV) is an emerging pathogen responsible for more than 20 million cases of acute hepatitis globally per annum. Healthy individuals typically have a self-limiting infection, …

2022年12月5日 · 81 genomic replicons (SGR) of HEV, we compared the effect of CypA and CypB pharmacological 82 and genetic inactivation on viral genome replication. Using this approach …

The dose-dependent inhibition of HEV (A) and HCV ( B ) replication by IFN-α2a and IFN-λ3 in Huh7.5 corresponds to Fig. 1, while the measuring window of the assay depicted in Fig. 3 is …

2022年12月5日 · Here, we investigated the importance of CypA and CypB for HEV genome replication using a sub-genomic replicon system. This system removes the requirements for …

2023年11月1日 · Hepatitis E virus (HEV) is an emerging pathogen responsible for more than 20 million cases of acute hepatitis globally per annum. Healthy individuals typically have a...

2023年7月21日 · To understand if any of these sites are important for virus replication, we utilised sub-genomic replicons (SGR) of both the G1 Sar55 HEV isolate and G3 HEV83-2-27 isolate, …

HEV is a positive-sense, single-stranded RNA virus of the Hepeviridae family. Although HEV accounts for more than 3 million symptomatic cases of viral hepatitis per year, specific anti …