Tuned by metals: the TET peptidase activity is controlled by 3 …
2016年2月8日 · Here, by means of anomalous x-ray crystallography and enzyme kinetics measurements of the TET3 aminopeptidase from the hyperthermophilic organism Pyrococcus …
Structure of anhydrotetracycline-bound Tet(X6) reveals the …
2023年4月17日 · Here, we present structural, biochemical, and phenotypic evidence that anhydrotetracycline binds in a substrate-like orientation and competitively inhibits the type 1 …
快速质谱法测定十一种十一种易位酶的催化活性,Analytical …
最近显示，十十一易位（tet）家族中的三个成员动态清除5mc在细胞分化中起关键作用。 TET酶属于Fe（II）和2-ketoglutarate（2KG）依赖的双加氧酶，可将5mC连续氧化为5-羟甲基胞嘧 …
Pronounced sequence specificity of the TET enzyme catalytic …
2022年9月7日 · We show that the intrinsic sequence preference of the TET catalytic domains significantly contributes to the establishment of DNA methylation patterns and TET function in …
Membrane Topology of the Staphylococcal Tetracycline Efflux Protein Tet ...
1998年12月1日 · Escherichia coli TG1 with the tet(K)-amp fusion gene at the site of the putative periplasmic loop showed resistance to ampicillin, but the bacterium with the tet(K)-cat fusion …
Tet：基于DNA去甲基化的全新抗肿瘤药物靶标 - shsmu.edu.cn
Tet特异识别基因组DNA上5-甲基胞嘧啶 (5mC) 的甲基并进行催化氧化，是哺乳动物基因组DNA主动去甲基化途径中唯一被发现的关键因子。 通过调控基因组5mC的动态平衡分布，Tet在胚胎 …
Pseudoenzymatic dealkylation of alkyltins by biological dithiols
We monitored the reaction kinetics using the intrinsic fluorescence of the tryptophan residue in position 5 of the peptide and found that all of the alkyltins analyzed are progressively …
上海光源用户揭示TET蛋白底物偏好性机制----上海光源（中文版）
2015年10月31日 · 这篇题为“Structural insight into substrate preference for TET-mediated oxidation”（晶体结构揭示TET蛋白介导的氧化反应底物偏好性机制）的研究论文，首次报道 …
Convert of 5-methylcytosine (5mC) to 5-hy-droxymethylcytosine (5hmC) by ten-eleven translocation (TET) family enzymes plays important biological functions in embryonic stem …
TET酶家族在神经胶质瘤干细胞中的分化调控机制及其潜在治疗靶 …
本文对TET酶家族在神经胶质瘤干细胞（glioma stem cell，GSC）分化过程中，通过去甲基化调控基因表达的具体机制及其在DNA损伤应答和修复过程的作用加以阐述，并对干预TET酶家族及 …