CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene …

2024年12月24日 · CHEK2 (Checkpoint Kinase 2) is a Protein Coding gene. Diseases associated with CHEK2 include Tumor Predisposition Syndrome 4 and Prostate Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).

The serine/threonine kinase CHK2 is a key component of the DNA damage response. In human cells, following genotoxic stress, CHK2 is activated and phosphorylates >20 proteins to induce the appropriate cellular response, which, depending on the extent ...

Checkpoint kinase 2 (Chk2) is a multifunctional enzyme whose functions are central to the induction of cell cycle arrest and apoptosis by DNA damage. Insight into Chk2 has derived from multiple approaches. Biochemical studies have addressed Chk2 structure, domain organization and regulation by phosp …

2009年9月24日 · The CHK2 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contributes to hereditary and sporadic cancer. CHK2 activation is triggered by the phosphorylation of Thr68 by the DNA damage-activated ATM kinase.

2023年12月19日 · CHEK2是 “检测点激酶2（checkpoint kinase2）” 基因的缩写。该基因为血细胞生产CHK2蛋白质提供指令，当细胞里的DNA损毁或DNA链断裂时，CHK2被激活。 CHK2蛋白质有什么作用？

CHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can prevent tumour...

2023年7月17日 · A CHEK2 gene mutation increases your risk for certain types of cancers. Your cancer risk may be different depending on the specific CHEK2 mutation you have. Most CHEK2 mutations increase your risk for breast cancer. Some of the most common CHEK2 mutations slightly increase your risk for colorectal (colon and rectal) cancer.

chk2蛋白激酶是dna损伤检查点信号的重要转导者，其突变有助于遗传和散发性癌症。 DNA损伤激活的ATM激酶使Thr68磷酸化，从而触发CHK2激活。 这导致瞬时的CHK2二聚化，部分地是通过分子间的磷酸化Thr68-FHA结构域相互作用。

该基因编码的蛋白质是细胞周期检查点调节剂和推定的肿瘤抑制因子。 它包含叉头相关蛋白相互作用结构域，该结构域对于响应 DNA 损伤的激活至关重要，并且响应复制块和 DNA 损伤而迅速磷酸化。 当被激活时，编码的蛋白质已知会抑制 CDC25C 磷酸酶，防止进入有丝分裂，并且已被证明可以稳定肿瘤抑制蛋白 p53，导致细胞周期停滞在 G1 期。 此外，这种蛋白质与 BRCA1 相互作用并磷酸化，使 BRCA1 在 DNA 损伤后恢复存活。 该基因的突变与 Li-Fraumeni 综合征有关， …