
Insights on hematopoietic cell kinase: An oncogenic player in …
2023年4月1日 · Abnormal activation or excessive expression of Hck is associated with cancer development, and it is potential that kinase inhibitors targeting Hck are a strategy for cancer …
Hematopoietic cell kinase (HCK) as a therapeutic target in …
Excessive HCK activation (↑ HCK) is a common observation in many solid cancers and enhances the recruitment of immune cells into tumors and promotes their proliferative and migratory …
Upregulation of haematopoetic cell kinase (Hck) activity by a …
2025年2月1日 · Ta9 upregulates the macrophage proto-oncogene hematopoietic cell kinase (HCK). Proliferation of T. annulata and T. lestoquardi infected leukocytes is HCK-dependent.
Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk …
2021年3月25日 · The average of bone marrow blasts was 77.88% (range 68–88%, being AML #1: 76%, AML #2: 68%, AML #3: 88%, AML #4: 85%, and AML #5: 72%). AML CD34 positive …
对造血细胞激酶的见解:人类癌症的致癌因素,Biomedicine
造血细胞激酶 (Hck) 是 Src 家族的成员,在造血细胞中表达。 通过调节多种信号通路,HCK 可以与多种受体相互作用,调节涉及细胞粘附、增殖、迁移、侵袭、凋亡和血管生成的信号事件。
造血细胞激酶(Hck)亚型和吞噬细胞功能-从信号传导和肌动蛋白 …
Hck主要在吞噬细胞中以两种亚型表达,即p59Hck和p61Hck,当在成纤维细胞中异位表达时,它们表现出不同的亚细胞定位并触发不同的表型。 据报道,Hck参与吞噬作用,粘附和迁移,并 …
Recent advances in hematopoietic cell kinase in cancer …
2024年7月1日 · Hck, a member of the non-receptor tyrosine kinase family, is recognized for its capacity to augment cell proliferation through the secretion of growth factors and pro …
HCK 原癌基因,Src 家族酪氨酸激酶(HCK)基因 | MCE
该基因编码的蛋白质是酪氨酸激酶 Src 家族的成员。 这种蛋白质主要是造血的,特别是在骨髓和 B 淋巴细胞谱系的细胞中。 它可能有助于将 Fc 受体与呼吸爆发的激活结合起来。 此外,它可 …
Clinicopathological value of hematopoietic cell kinase …
Upregulated HCK mRNA displayed a moderate discriminatory ability between LSCC tissues and non-tumor laryngeal epithelial controls (area under the curve = 0.78, sensitivity = 0.76, …
HCK人源基因|HCK基因突变_致病性_靶点-RDDC官网
这个基因编码的蛋白质是Src家族酪氨酸激酶成员。 这种蛋白质主要在造血细胞中表达,特别是在髓系和B淋巴细胞谱系的细胞中。 它可能有助于将Fc受体与呼吸爆发的激活耦合。 此外,它 …