2017年10月13日 · Here, we report the identification of a new paxillin-binding protein, PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, number 3), which is involved in regulation of the subcellular localization of paxillin.

We have isolated a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF), paxillin-associated protein with ARFGAP activity (PAG)3/Papα/KIAA0400, from mature monocytes and macrophage-like cells. Mammalian ARFs fall into three classes, and the class III isoform (ARF6) has been shown to be involved in FcγR-mediated phagocytosis.

Here, we report the identification of a new paxillin-binding protein, PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, number 3), which is involved in regulation of the subcellular localization of paxillin.

2022年11月29日 · Results: The procyclin associated gene 3 (PAG3) can be found in the pleomorphicspecies, T.brucei, which undergoes differentiation of slender forms to the stumpy form. This differentiation process is crucial for transmission to the tsetse fly vector.

2000年5月1日 · Here, we report the identification of a new paxillin-binding protein, PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, number 3),...

2001年4月16日 · We propose that PAG3 acts as a GAP for ARF6 and is hence involved in FcgammaR-mediated phagocytosis in mouse macrophages. The Fcgamma receptor (FcgammaR)-mediated phagocytosis of macrophages is a complex process where remodeling of both the actin-based cytoskeleton and plasma membrane occur coordinately.

Here, we report the identification of a new paxillin-binding protein, PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, numbe... ......

PAG3 binds to paxillin and serves as a GAP for Arf6. Overex-pression of PAG3 in fibroblasts inhibits cell motility and re-duces the paxillin recruitment to focal contacts in a GAP-de-pendent manner (31). These results suggest that PAG3 plays a role in mediating changes in cell motility. To find additional functions of POB1, we screened proteins

Target Summary: PAG3 (paxillin-associated protein with ADP-ribosylation factor [ARF] GTPase-activating protein [GAP] activity, number 3) is a member of the ARF GAP family of proteins that associates with the

Phenyl amino glutarimide (PAG) 3'-piperazine-4-methylpiperidine is a functionalized cereblon ligand for PROTAC ® research and development. Incorporates an E3 ligase ligand with a terminal piperidine for onward chemistry to generate Protein Degraders with rigid linkers. Part of a range of functionalized tool molecules for PROTAC R&D.