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该基因编码属于 I 型细胞因子受体家族的蛋白质。 这种蛋白质与高亲和力转换器亚基 gp130 结合，形成受体复合物，介导白血病抑制因子的作用，白血病抑制因子是一种多功能细胞因子，参与成人和胚胎的细胞分化、增殖和存活。 该基因的突变会导致 2 型 Schwartz-Jampel 综合征，这是一种属于弯曲骨发育不良的疾病。 涉及该基因启动子的易位，t (5;8) (p13;q12) 与多形性腺瘤基因 1，与唾液腺多形性腺瘤有关，唾液腺多形性腺瘤是唾液腺的一种常见良性上皮肿瘤。 已为该 …

2021年4月29日 · Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors a …

LIF/LIFR 激活致癌信号通路，包括作为直接效应器的 JAK/STAT3 和下游的 MAPK、AKT、mTOR。 LIF/LIFR 信号在肿瘤生长、进展、转移、干细胞性和治疗耐药性中发挥着关键作用。 许多实体癌表现出 LIF 的过度表达和 LIF/LIFR 轴的自分泌刺激；这些与较差的无复发生存率有关。 LIF/LIFR 信号传导还在调节肿瘤微环境 (TME) 中存在的多种免疫细胞类型中发挥作用。 最近，两种针对LIF（人源化抗LIF抗体，MSC-1）和LIFR抑制剂（EC359）的靶向药物正在开发中。 …

2024年8月16日 · 通过单细胞质谱流式技术 （CyTOF） 、脂质组学 （lipidomics） 及进一步研究，团队揭示了这一过程的分子机制：LIFR通过激活STAT3信号通路，促进肝细胞生成及分泌胆固醇和趋化因子CXCL1。这些分泌物激活了骨髓中性粒细胞，使其进入血液循环和肝脏。

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The investments have the approval of the Shariah Advisor/Shariah Board of TPL Life Insurance, Window Takaful Operations. Is Risk Protection (insurance) against Tawakkul (total dependence upon Allah (SWT)?

2024年12月12日 · First of its Kind in Pakistan, Buy Digital Products for Health and Epidemic through TPL Life app. The one stop solution for all your life and health insurance needs. Manage multiple policies of...

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