High TMTV at baseline was significantly associated with inferior PFS and OS in patients receiving either lenalidomide maintenance or placebo. Baseline TMTV combined with ECOG PS could improve risk stratification for patients who respond to R-CHOP induction, meeting an unmet need for early and better identification of ultra-risk DLBCL patients.

2020年7月28日 · Total metabolic tumor volume (TMTV) is a promising quantitative biomarker for therapy assessment and prognosis in Hodgkin Lymphoma affected patients that allows...

基线肿瘤代谢指标包括最大葡萄糖标准摄取值（SUVmax）、平均摄取值（SUVmean）、总肿瘤代谢体积（TMTV）、总糖酵解率（TLG）。 分析肿瘤代谢参数及临床和血液学相关指标对治疗的影响。 结果 51例患者中，20例复发或进展，中位无进展生存（PFS）期时间为12.0个月（1.0~64.0个月），2年PFS率为25.5%（13/51）。 TMTV、TLG与血清乳酸脱氢酶（LDH）水平的相关性较强。 单因素分析显示Ann Arbor分期、NCCN-IPI评分、TMTV均对预后有显著相关 …

2018年3月29日 · The prognostic value of TMTV was evaluated and compared with baseline characteristics, staging classifications, and iPET2. A total of 258 patients were eligible: 101 favorable and 157 unfavorable. The median follow-up was 55 months, with 27 progression-free survival (PFS) and 12 overall survival (OS) events.

基线PET对总体代谢肿瘤体积（TMTV）进行检查。 IPET2的结果用Deauville量表标记阴性（DS1- 为更好的 筛查 早期霍奇金 淋巴瘤 （HL）的高危患者，研究人员对基线PET/CT作为总体肿瘤负荷检测方法进行验证。 研究人员筛选 临床 试验H10（NCT00433433）的标准臂里有基线PET和阿霉素、博来霉素、长春花碱和达卡巴嗪治疗两个疗程后的即时PET (iPET2)相关数据的I-II期的HL患者。 基线PET对总体代谢肿瘤体积（TMTV）进行检查。 IPET2的结果用Deauville量表标记阴 …

2022年2月2日 · A total of 258 patients, including 101 classified as early-stage favorable and 157 as early-stage unfavorable disease, had their baseline TMTV calculated by the 41% SUVmax threshold by three different nuclear medicine specialists.

2024年8月1日 · Pretreatment total metabolic tumor volume (TMTV), measured using 18F-FDG PET/CT, provides prognostic information, and TMTV, alone or in combination with other clinical risk factors, out-performs commonly used international prognostic scores ( 2,6–11). TMTV also offers a more accurate refl ection of risk than do tradi-

2020年7月23日 · tmtv是r-chop初始治疗有效患者生存结局的有力预后指标，在接受来那度胺维持或安慰剂治疗的患者中，高基线的tmtv与较差pfs和os显着相关。 基线TMTV结合ECOG PS可以改善对R-CHOP诱导有反应的患者的风险分层，满足早期和更好地识别超高风险DLBCL患者的需求。

2018年4月4日 · High total metabolic tumor volume (TMTV), computed from baseline 18 F-fluorodeoxyglucose–positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTCs) and cell-free DNA (cfDNA) may also reflect tumor burden and be of prognostic value.

2023年10月24日 · The LyMa-101, a phase 2 trial of the LYSA group (ClinicalTrials.gov:NCT02896582) reported induction therapy with obinutuzumab, a CD20 monoclonal antibody. Herein, we investigated the added prognostic value of radiomic features (RF) derived from FDG-PET/CT at diagnosis for MRD value prediction.