2003年8月1日 · Molecular studies have identified a human homologue of the drosophila trithorax gene (designed HRX or MLL). MLL is a developmental regulator and is structurally altered in …

2008年世界卫生组织(World Health Organization，WHO)将具有t(v；11q23)MLL重排的ALL列为急性白血病的一种亚型，该类型白血病患者大多具有恶性程度高、化疗不敏感、预后不佳等特 …

Aim: To detect the frequency, diagnostic and prognostic significance of 11q23/MLL rearrangements and to determine the chromosomes that are most frequently involved in …

2021年12月10日 · Acute lymphoblastic leukemia (ALL) with t (4;11) (q21;q23)-KMT2A-AFF1 is associated with a poor prognosis. The impact of KMT2A rearrangements other than t (4;11) is …

Structural abnormalities involving the long arm of chromosome 11, region 2, band 3 (11q23), are cytogenetic changes consistently seen in hematopoietic malignancies, including acute myeloid …

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More …

Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous …

混合系谱白血病（Mixed lineage leukemia，MLL）基因异常发生在染色体11q23上，成人AML发生率为5％左右 [1]。 1979年，Van den Berghe等 [2] 首先报道了急性淋巴细胞白血病（ALL）中 …

2004年2月1日 · There is strong molecular evidence that 11q23 abnormalities in infants with ALL occur in utero. The 11q23 band/MLL gene has an important role in normal hematopoietic …

The MLL gene, located at chromosome 11, band q23, is frequently disrupted by a variety of chromosomal rearrangements that occur in acute lymphoblastic leukemias and in a subset of …