Rearrangements of the MLL gene located at 11q23 are common chromosomal abnormalities associated with acute leukemia (AL), especially infant and secondary leukemia after previous …

2003年8月1日 · Molecular studies have identified a human homologue of the drosophila trithorax gene (designed HRX or MLL). MLL is a developmental regulator and is structurally altered in …

2003年10月1日 · Acute myeloid leukemia (AML) cases with 11q23 abnormalities involving the MLL gene comprise one category of recurring genetic abnormalities in the WHO classification. …

We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a reciprocal translocation involving the 11q23 locus (MLL) who were treated at …

Aim: To detect the frequency, diagnostic and prognostic significance of 11q23/MLL rearrangements and to determine the chromosomes that are most frequently involved in …

2017年1月23日 · Mixed lineage leukemia (MLL), encoded by the lysine (K)-specific methyl transferase 2A (KMT2A) gene at 11q23, is a H3K4me3-depositing protein active during early …

The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately …

混合系谱白血病（Mixed lineage leukemia，MLL）基因异常发生在染色体11q23上，成人AML发生率为5％左右 [1]。 1979年，Van den Berghe等 [2] 首先报道了急性淋巴细胞白血病（ALL）中 …

2009年9月17日 · Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene …

1993年9月23日 · We identified DNA rearrangements in 61 patients and 3 cell lines with 11q23 abnormalities and delineated an 8.3-kb breakpoint cluster region within the MLL gene by using …