129 mice are known for having a higher likelihood of developing certain diseases such as cancer and diabetes, making them valuable for research in those areas. They also have a docile temperament, making them easy to handle and work with in laboratory settings.

002448 129S1/SvImJ 129 mice are widely used in the production of targeted mutations due to the availability of multiple embryonic stem cell lines derived from them. They also have a high incidence of spontaneous testicular teratomas.

2012年，维通利华对该品系进行了clone back，2019年和2024年，重新从Charles River引入该品系隔离器核心群。 研究用途： 转基因和基因敲除模型；生殖生理研究；肿瘤学研究；饲料诱 …

129小鼠的特点与应用. 129小鼠不同亚系之间有明显差别，一般来说，具有如下特点。 （1) 广泛应用于基因工程。 包括用于建立 转基因 、 基因敲除小鼠 。 （2) 肢体运动神经元轴突脱髓鞘。 （3) 自发性先天性睾丸畸胎瘤。

The 129S2/SvPasOrl strain is a substrain of Steel, resulting from crossbreeding with the C3H-MgfSl-J, followed by 12-14 generations of further crossbreeding with 129/Sv stock. This resulted in mice with agouti pigmentation and white bellies. The steel-J mutation increases the incidence of tertomas by 10%.

Homozygous AG129 mice are viable and fertile, and exhibit increased sensitivity to arboviral infections, generating viremia similar to that seen in humans. Compared to IFNα/β/γR KO mice on the C57BL/6 background, the 129-background AG129 mice exhibit more pronounced neurological symptoms after infection [6,9]. Strain Strategy

A large proportion of 129/Ola mice have major shunts between the hepatic portal system and the vena cava, allowing the passage of microspheres up to 50m in diameter.. These shunts are associated with resistance to Shistosoma japonicum cercariae (Coulson and Wilson 1989).

129小鼠（129 mouse）是最常使用的实验动物。毛色：野生色（Agouti）。 129小鼠的诞生. 在1928年，Dunn（L.C.Dunn）将来自英国繁殖的小鼠与Castle(W.Castle)的灰色小鼠进行交配，通过近交培育而成。发现自发性睾丸畸胎瘤的发生率比较高。 129小鼠有多个亚系，根据命名 ...

Charles River provides laboratory animals, including 129 mice, for use in basic research and nonclinical drug discovery and development.

2025年3月18日 · Because of the importance of 129 mice in creating "knockout" and other targeted mutant mice, the International Committee on Standardized Genetic Nomenclature for Mice introduced a nomenclature to distinguish different 129 parental lines and related 129 strains.