The minimal deleted region (MDR)/small deletion or long 13q loss/mutation, and biallelic 13q deletion or monoallelic 13q deletion are commonly seen. 13q14 deletion is an initiating defect targeting tumor suppressor gene locus deleted in lymphocytic leukemia 2 (DLEU2))/microRNA15A (MIR15A)/microRNA 16-1 (MIR 16-1).

2011年10月31日 · In this report, we provide evidence that large 13q14 deletions that are inclusive of the retinoblastoma gene (RB1) are prognostically adverse and that these deletions are frequently associated with unstable CLL genomes.

2021年8月2日 · The minimal deleted region (MDR)/small deletion or long 13q loss/mutation, and biallelic 13q deletion or monoallelic 13q deletion are commonly seen. 13q14 deletion is an initiating defect targeting tumor suppressor gene locus deleted in lymphocytic leukemia 2 (DLEU2))/microRNA15A (MIR15A)/microRNA 16-1 (MIR 16-1).

Deletion 13q14 on fluorescence in situ hybridization (FISH) analysis is the most common cytogenetic abnormality in chronic lymphocytic leukemia (CLL), and is a favorable prognostic biomarker when detected as a sole abnormality.

FISH具有快速灵敏、特异性高、不需要中期分裂相的特点，弥补了常规染色体核型检测需要中期分裂相、分辨率低的不足，成为MM遗传学检测的主要方法。 近年来，虽然遗传学检测对于MM的重要意义已经取得共识，但国内MM遗传学检测存在检测方法不规范、阳性阈值混乱、临床价值不明确等一系列问题，亟需进一步规范。 为此我们制订了MM的遗传学检测专家共识，以规范国内MM的遗传学检测。 MM肿瘤细胞为终末分化细胞，增殖率较低，传统的染色体制备很难获得 …

Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical …

2012年11月16日 · Therefore, the primary endpoints of our research were: 1) to determine progression free survival (PFS) and overall survival (OS) on the basis of percentages of 13q- nuclei and 2) to confirm 13q14 number of deleted cells as an independent prognostic factor. We investigated 503 pts, median age 65 years (range 33–89), 291 males and 212 females.

2000年3月15日 · We found that despite the fact that FISH studies revealed 13q14 deletions in at least twice as many patients with MM as did metaphase analysis, the presence of a 13q14 deletion was the most important independent variable associated with inferior outcome after conventional-dose chemotherapy.

13q14缺失是多发性骨髓瘤患者最常见的核型异常之一，也是荧光原位杂交技术(fluorescence in situ hybridization，FISH)中的常用指标 。因此，基于细胞遗传学构建预后危险分层体系对于患者的个体化治疗有显著临床意义。

The novel findings from this study are i) that 13q14 deletions have varying effects on CLL clinical behavior, with large 13q14 deletions (type II: inclusive of RB1) associated with an inferior prognosis; ii) that 13q14 type II deletions are frequently associated with additional aCNA (a total aCNA count of ≥3 was detected in ~35% of cases ...