Human 15S-lipoxygenase-2 (15-LOX-2) is a recently identified lipoxygenase that has approximately 40% sequence identity to the known human 5S-, 12S-, and 15S-lipoxygenases. 15-LOX-2 has a limited tissue distribution, with mRNA detected in prostate, lung, skin, and cornea, but not in numerous other ti …

15-脂氧合酶 (15-LOX)是催化不饱和脂肪酸代谢的关键酶之一.人类中存有两型15-LOX:15-LOX-1和15-LOX-2,两者在催化性质,组织分布及肿瘤生物学功能上有所差异.近年来大量研究发现15-LOX在结肠癌,前列腺癌,食道癌等恶性肿瘤表达较正常组织降低,能够抑制肿瘤生长,并使其发生凋亡,在肿瘤发生发展中起着重要作用.以15-LOX为靶向的肿瘤防治及其临床应用具有广阔的前景. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的 …

2014年3月3日 · We report here the crystal structure of human 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.

2014年8月11日 · This study employs high throughput screening to identify two novel, specific 15­LOX­2 inhibitors. MLS000545091 is a mixed-type inhibitor of 15-LOX-2 with a Ki of 0.9+/−0.4 µM and has a 20-fold selectivity over 5-LOX, 12-LOX, 15-LOX-1, COX-1, and COX-2.

2024年12月19日 · The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio- and stereospecific oxygenation of arachidonate to its corresponding hydroperoxide (15 (S)-HpETE). h15-LOX-2 is implicated in the biosynthesis of inflammatory lipid mediators and plays a role in the development of atherosclerotic plaques, but it is still underexploited as a drug ...

2006年4月1日 · 15-lipoxygenase (15-LOX) belongs to the structurally and functionally related nonheme iron dioxygenases family. It has two isoforms, type-1 (leukocyte type) and type-2 (epidermis type) and converts arachidonic acid to eicosanoids including the anti-cancer 13-HODE.

The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio- and stereospecific oxygenation of arachidonate to its corresponding hydroperoxide (15­(S)-HpETE). h15-LOX-2 is implicated in the biosynthesis of inflammatory lipid mediators and plays a role in the development of atherosclerotic plaques, but it is still underexploited as a ...

2023年12月5日 · Dual-acting COX-2/5-LOX inhibitors may treat cancer by suppressing COX-2 and 5-LOX enzymes. 15-LOX inhibitors lack some of the side effects of 5-LOX inhibitors. Implications of novel synthetic analogs as dual COX-2/15-LOX inhibitors are addressed in the present review paper.

在这里，我们描述了 COX-2、15-LOX 和 PPARγ 在癌症和代谢紊乱并发症中的作用，强调了设计多靶点定向配体 (MTDL) 以改变其活性的价值，并总结了有关基本原理的现有文献以及这些配体的设计和合成的可行性以及它们已知的生物学效应。 我们推测 MTDLs 在这些疾病中的潜在影响，并强调需要结构化的未来努力来转化这些早期结果，以促进在临床研究中采用这些和类似的分子。 对此类多方面疾病的有效治疗干预需要同时调节多个目标。 在这里，我们描述了 COX-2、15 …

2018年6月7日 · 15-LOX can be subclassified according to specificity of tissue distribution and enzymatic characteristics into 15-LOX-1 and 15-LOX-2. 15-LOX-1 catalyzes deoxygenation of linoleic acid and arachidonic acid, and produces 13-S-hydroxyoctadecadienoic acid (13 (S)-HpODE) and 15-S-hydroxyeicosatetraenoic acid (15 (S)HpETE) as its primary products, res...