Small molecule inhibitors of 15-PGDH exploit a physiologic
2023年2月11日 · 15-prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that acts via enzymatic activity of oxidizing and degrading PGE2, and related...
Inhibition of prostaglandin-degrading enzyme 15-PGDH
2021年1月29日 · Inhibition of 15-PGDH, by targeted genetic depletion or a small-molecule inhibitor, increased aged muscle mass, strength, and exercise performance. These benefits …
15-PGDH | 15-羟基前列腺素脱氢酶 | 抑制剂 | MCE
15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzyme in the degradation of prostaglandins, including prostaglandin E2 (PGE2). 15-PGDH can catalyze the conversion of …
Inhibition of the prostaglandin-degrading enzyme 15-PGDH ... - Science
2015年6月12日 · We used 15-PGDH knockout mice to elucidate the role of 15-PGDH in regulating tissue levels of PGE2 and tissue repair capacity in multiple organs. We then …
Recent advances in studies of 15-PGDH as a key enzyme for the ...
2021年12月1日 · 15-PGDH is a key enzyme in degrading PGs, including PGE 2, by catalyzing the transformation of the 15-hydroxyl group of PGE 2 to 15-keto-PGE 2, resulting in biologically …
Therapeutic targeting of 15-PGDH in murine pulmonary fibrosis …
2020年7月15日 · Here we evaluated pulmonary 15-PGDH expression and activity and tested whether pharmacologic 15-PGDH inhibition (PGDHi) is protective in a mouse model of …
Tumour suppressor 15-hydroxyprostaglandin dehydrogenase …
2020年8月19日 · The tumour suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is an enzyme responsible for the degradation of PGE 2 into an inactive metabolite 15. 15-PGDH …
15-PGDH作为降解前列腺素关键酶的研究进展 ... - X-MOL
15-hydroxyprostaglandin dehydrogenase (15-PGDH; encoded by HPGD) is ubiquitously expressed in mammalian tissues and catalyzes the degradation of prostaglandins (PGs; …
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH
2023年11月7日 · Our study provides new insights into the role of 15-PGDH in acute lung rejection and highlights the therapeutic potential of inhibiting 15-PGDH for enhancing graft survival. The …
15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents …
2017年4月19日 · The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the …