Here, we reviewed the pre-clinical data and clinical trial data on 17-DMAG as a single agent, in combination with other agents and loaded on nanomaterials in various cancers and …

2017年9月4日 · Treatment of Ercc1 −/∆ mice, a mouse model of a human progeroid syndrome, with the HSP90 inhibitor 17-DMAG extended healthspan, delayed the onset of several age …

17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin. [1] [2] It is being studied for …

An HSP90 ATPase activity assay indicated that 17-DMAG inhibits the ATPase activity of HSP90 by binding to its ATPase domain (Figure 2B). 17-DMAG dose-dependently increased the …

2018年6月1日 · Co-treatment with 17- DMAG and vorinostat (pan-histone deacetylase inhibitor) synergistically induces the apoptosis of MCL cells. 17-DMAG promotes proteasomal …

A geldanamycin analog, 17-Dimethylamino-ethylamino-17-demethoxygeldanamycin (17-DMAG), an HSP90 inhibitor, is characterized by a more water-soluble and less hepatotoxic . 17-DMAG …

Using an MCA205 sarcoma model, we show that in vitro treatment of tumor cells with the HSP90 inhibitor 17-DMAG results in the transient (proteasome-dependent) degradation of the HSP90 …

2007年6月20日 · Background: 17-DMAG binds to heat-shock protein 90, leading to degradation of oncogene client proteins, inhibiting tumor growth. Preclinically, 17-DMAG has potent antitumor …

2025年1月7日 · 17-DMAG is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as …

2013年8月16日 · Administration of a novel water-soluble and less toxic GA derivative, 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG), to Tax …