2021年5月1日 · In this study, we designed and synthesized the 18 F-labeled pyridine based benzamide derivative N - (2- (dimethylamino)ethyl)-5- [18 F]fluoropicolinamide ( [18 F]DMPY2) and compared with conventional positron emission tomography (PET) imaging agents in early stage primary and metastatic melanoma animal models.

18F-Fbza | C13H19FN2O | CID 16119184 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2014年9月1日 · Benzamide can specifically bind to melanoma cells. A 18 F-labeled benzamide derivative, [18 F] N - (2-diethylaminoethyl)-4- [2- (2- (2-fluoroethoxy) ethoxy)ethoxy]benzamide ( [18 F]FPBZA), was developed as a promising PET probe for primary and metastatic melanoma. Methods. [18 F]FPBZA was synthesized via a one-step radiofluorination in this study.

In summary, we report the development of a novel 18 F-labeled aliphatic compound for melanoma imaging that can be easily synthesized in high yields using the radiosynthon 18 F-NFP. The PET probe 18 F-FPDA exhibits high B16F10 tumor-targeting efficacy and favorable in vivo pharmacokinetics.

2009年11月19日 · Whole-body PET imaging with 18 F-labeled fluorodeoxyglucose ( [18 F]FDG) has been shown to be superior to conventional imaging for detection of metastatic diseases, but it has not been shown to be useful for detecting small metastatic tumors (7, 8).

In summary, a novel 18 F-labeled PET imaging probe, 18 F-FBZA, was successfully synthesized via a one step conjugation reaction between the radiosynthon, 18 F-SFB and DEDA. 18 F-FBZA was found to specifically target both primary and pulmonary melanotic metastastic lesions with high tumor uptakes and good tumor to normal tissue ratios.

A 18F-labeled benzamide derivative, [18F]N- (2-diethylaminoethyl)-4- [2- (2- (2-fluoroethoxy) ethoxy)ethoxy]benzamide ( [18F]FPBZA), was developed as a promising PET probe for primary and metastatic melanoma.

六名健康志愿者被注射了 18 F-P3BZA（211.7±15.4 MBq），然后进行连续全身PET / CT扫描和血液检查，以评估注射后10分钟，1小时，2小时和4小时的生物分布，药代动力学和放射剂量。 在成像期间定期记录志愿者的生命体征。 使用OLINDA / EXM软件计算医学内部辐射剂量方案后每个受试者的有效剂量。 对于初步临床应用，在注射后10分钟和1小时，对5名疑似黑色素瘤患者进行了 18 F-P3BZA PET / CT成像。 所有患者在第三天也进行了 18 F-FDG PET / CT扫描，以比较 18 …

开发了4-10B-Borono-2-18F-氟-L-苯丙氨酸（18F-FBPA）来监测用于硼中子俘获治疗（BNCT）的4-10B-borono-L-苯丙氨酸（10B-BPA）的药代动力学正电子发射断层扫描（PET）。 在各种动物模型中均证实了18F-FBPA的肿瘤成像潜能。

In particular, 18F-FDS can distinguish pulmonary aspergillosis from Staphylococcus aureus infection, both of which induce pulmonary infiltrates in immunocompromised patients.