2021年4月29日 · Gain of chromosome 1q (+1q) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly diagnosed...

1q21.1 microdeletion is a chromosomal change in which a small piece of chromosome 1 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome in a region designated q21.1.

2011年2月24日 · The 1q21.1 recurrent deletion itself does not lead to a clinically recognizable syndrome, as some persons with the deletion have no obvious clinical findings.

骨髓瘤主要遗传学异常包括染色体1q21的扩增、13q14缺失，免疫球蛋白重链(IGH)基因重排和17p13(p53)缺失等 ，1号染色体的异常在骨髓瘤中常见，主要有1q获得及1p缺失，虽然1q21扩增是MM常见的遗传学异常，但是目前尚未被列为MM常规的遗传学检测项目 。本研究回顾性 ...

Amplification of chromosome 1q (1q21 amp) is one of the most common secondary cytogenetic abnormalities in patients with MM. 1q21 amp is often associated with poor prognosis, drug resistance, and disease progression . The 1q21 region is known to contain several oncogenes and genes that may show simultaneous amplification and/or deregulated ...

1q21.1 microduplication is a chromosomal change in which a small amount of genetic material on chromosome 1 is abnormally copied (duplicated). The duplication occurs on the long (q) arm of the chromosome at a location designated q21.1.

1q21扩增（以下简称1q）是多发性骨髓瘤（multiple myeloma，MM）中常见的一种细胞遗传学异常，2016年国际骨髓瘤工作组（IMWG）将1q定义为高危遗传学异常之一 [1]。 然而，1q对MM患者的疗效反应和生存的确切影响尚不明确 [2] – [6]，且对该高危亚型仍缺乏有效的、能改善患者生存的治疗手段 [7] – [9]。 在本研究中我们回顾性分析了伴和不伴1q的初治MM患者临床特征、细胞遗传学异常、疗效和预后，同时利用公共数据库比较了伴和不伴1q MM样本基因表达 …

Looking at chromosome 1q Chromosomes can’t be seen with the naked eye, but if they are stained and magnified under a microscope, each one has a distinctive pattern of light and dark bands. Looking at chromosomes in this way, it is possible to see the points where the chromosome has broken and what material

Gain of chromosome 1q (+1q) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM), occurring in approximately 40% of newly...

2024年10月5日 · Chromosome 1q copy number variations, collectively termed +1q, are 1 of the most common cytogenetic abnormalities in multiple myeloma. 1q abnormalities are associated with overexpression of a high-risk gene signature promoting cell proliferation, apoptosis resistance, genomic instability, and treatment resistance, and acquisition or expansion ...