Thermo Scientific Pierce 2-Mercaptoethylamine-HCl, commonly abbreviated 2-MEA, is a mild reductant that is often used to selectively reduce hinge-region disulfide bonds in antibody.

2-Mercaptoethylamine•HCl (2-MEA) is a mild reducing agent suitable for selectively cleaving hinge-region disulfide bonds of IgG heavy chains. Several popular methods for conjugation or immobilization of antibodies involve covalent attachment specifically …

2016年9月21日 · 双特异性抗体（bispecific antibody, BsAb），与普通抗体相比具有更强特异性和杀伤效应，另外还有具有降低耐药性，应用到免疫疗法等显著优势。 对于双特异性抗体的技术平台以及格局armstrong在114个在研双特异性抗体药物统计一文中有了详尽的介绍，这里不加赘述[3]。 DuoBody platform是其中的一种双特异性抗体生成技术平台，能够快速、稳定以及规模化生产的双特异性抗体。 DuoBody platform操作相对简单，仅需在两个IgG1抗体的Fc CH3区域分别引 …

中文名:半胱胺盐酸盐,英文名:2-Aminoethanethiol hydrochloride,CAS:156-57-0,化学式:C2H8ClNS,分子量:113.61,密度:0.75,熔点:67-71°C,沸点:238.5℃ [at 101 325 Pa],闪点:24.2°C,水溶性:VERY SOLUBLE,蒸汽压:5.333Pa at 25℃,折射率:1.6100 (estimate),MSDS.

使用 2-巯基乙胺·HCl（2-MEA）略微还原 F（ab'）2 片段。 可以靶向结合每个 Fab’ 的游离巯基，或使用烷基化试剂（例如 N-乙基马来酰亚胺，NEM）进行封闭，防止重新形成 F（ab'）2。

2-Mercaptoethylamine•Hl (2-MEA) is a mild reducing agent suitable for selectively cleaving hinge-region disulfide bonds of IgG heavy chains. Several popular methods for conjugation or immobilization of antibodies involve covalent attachment

Thermo Scientific Pierce 2-Mercaptoethylamine-HCl, commonly abbreviated 2-MEA, is a mild reductant that is often used to selectively reduce hinge-region disulfide bonds in antibody.

别名: β-巯基乙胺, 2-巯基乙胺, 2-氨基乙硫醇, mea, 巯基乙胺, 硫化乙醇胺

2-巯基乙胺（2-meFra Baidu bibliotekcaptoethylamine，2-MEA）还原反应是一种常见的有机合成反应，通常用于还原亲电性官能团（如烯烃、醛、酮和炔烃）。 2-MEA是一种硫醇化合物，它具有强还原性，可以作为还原剂参与反应。

Use 2-Mercaptoethylamine•HCl (2-MEA) for mild reduction of F(ab')2 fragments. The free sulfhydryls of each Fab' can be targeted for conjugation, or they can be blocked with an alkylating reagent, such as N-Ethylmaleimide (NEM) to prevent re-formation of the F(ab')2.