20-羟-二十烷四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)是花生四烯酸的细胞色素P-450代谢途径的一个重要代谢产物·近年来研究发现20-HETE对血管内皮细胞发挥重要的生理和病理生理作用·20-HETE可激活内皮细胞烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide phosphate,NADPH ...

20-Hydroxyeicosatetraenoic acid, also known as 20-HETE or 20-hydroxy-5 Z,8 Z,11 Z,14 Z -eicosatetraenoic acid, is an eicosanoid metabolite of arachidonic acid that has a wide range of effects on the vascular system including the regulation of vascular tone, blood flow to specific organs, sodium and fluid transport in the kidney, and vascular pat...

20-hete是一种有效的血管收缩剂，最近被证明是由神经血管单位的细胞产生的，是肌生成反应和脑血流自我调节的关键介质。20-hete产生的基因变异先前与高血压和中风有关，现在有初步报告称它们也可能与阿尔茨海默病和相关痴呆有关。

20-HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent effects on the vasculature including stimulation of smooth muscle cell contractility, migration and proliferation as well as activation of endothelial cell dysfunction and ...

Arachidonic acid (AA) is metabolized by enzymes of the CYP4A and 4F families to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the regulation of renal function, vascular tone and the long term control of arterial pressure.

20-hete是一种细胞色素p450（cyp450）代谢产物，据推测在脑血管和肾血管中起着自分泌作用。 在大鼠脑微血管中，这种化合物是一种介导压力诱导的自主调节性血管收缩的血管收缩剂。

2023年1月1日 · 20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid shown to be instrumental in the regulation of endothelial function, vascular tone, vascular remodeling and blood pressure; working alone and in concert with an array of mediators that influence vascular function.

20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid shown to be instrumental in the regulation of endothelial function, vascular tone, vascular remodeling and blood pressure; working alone and in concert with an array of …

血管活性类二十烷酸 20-羟基二十碳四烯酸 (20-hete) 是该系统中的关键角色，影响血管系统对收缩肌刺激的敏感性、调节内皮功能、影响肾素血管紧张素系统 (ras)，同时也是驱动因素血管重塑与血压升高无关。

The vasoactive eicosanoid, 20-Hydroxyeicosatetraenoic acid (20-HETE) is a key player in this system influencing the sensitivity of the vasculature to constrictor stimuli, regulating endothelial function, and influencing the renin angiotensin system (RAS), as well as being a driver of vascular remodeling independent of blood pressure elevations.