Malic enzyme 2 maintains metabolic state and anti-tumor ... - Cell …
2024年8月15日 · ME2 deficiency suppresses CD8 + T cell activation and anti-tumor immune response in vitro and in vivo. Mechanistically, ME2 depletion blocks the TCA cycle flux, …
AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic
2024年1月23日 · Here we report that activated AKT1 directly phosphorylates ME2 at serine 9 in the cytosol, leading to a discovery of a cytoplasmic form of ME2, ME2fl. In contrast to the …
Knockdown of Malic Enzyme 2 Suppresses Lung Tumor Growth
2014年6月24日 · Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of malate to yield CO 2 and pyruvate, with concomitant reduction of dinucleotide...
SIRT5-mediated ME2 desuccinylation promotes cancer growth by …
2023年11月25日 · In this study, we demonstrate that ME2 is highly expressed in human colorectal cancer (CRC) tissues, and that ME2 knockdown inhibits the proliferation of CRC cells. …
ME2 Gene - GeneCards | MAOM Protein | MAOM Antibody
2024年12月25日 · ME2 (Malic Enzyme 2) is a Protein Coding gene. Diseases associated with ME2 include Febrile Seizures, Familial, 8 and Opioid Dependence 1 . Among its related …
2-Methoxyestradiol (2-ME2，二甲氧基雌二醇) - 仅供科研
2-Methoxyestradiol (2-ME2)，具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物，是凋亡 (apoptosis) 诱导剂和血管生成 (angiogenesis) 抑制剂，具有有效的抗肿瘤活性。 2 …
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to ...
2021年5月4日 · Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate binds …
突破！江南大学附属医院黄朝晖团队：揭示苹果酸酶2琥珀酰化调 …
2023年12月1日 · 导读：苹果酸酶2（malic enzyme 2, ME2）是一种定位于线粒体的代谢酶，催化苹果酸氧化脱羧生成丙酮酸，并伴随产生NADPH。 近年来，研究揭示ME2在肿瘤中异常高表 …
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to ...
2021年5月4日 · Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate binds …
Meyer ME2-CP24 Chef's Pan, 9.4 inches (24 cm), Stainless Steel ...
Buy Meyer ME2-CP24 Chef's Pan, 9.4 inches (24 cm), Stainless Steel, Fluorine Resin Treatment, Compatible with All Heat Sources, 3-Layer Bottom, Stainless Steel: Wire - Amazon.com FREE …