2024年8月15日 · ME2 deficiency suppresses CD8 + T cell activation and anti-tumor immune response in vitro and in vivo. Mechanistically, ME2 depletion blocks the TCA cycle flux, leading to the accumulation of fumarate. Fumarate directly binds to DAPK1 and inhibits its activity by competing with ATP for binding.

2024年1月23日 · Here we report that activated AKT1 directly phosphorylates ME2 at serine 9 in the cytosol, leading to a discovery of a cytoplasmic form of ME2, ME2fl. In contrast to the direct role of...

2014年6月24日 · Mitochondrial malic enzyme 2 (ME2) catalyzes the oxidative decarboxylation of malate to yield CO 2 and pyruvate, with concomitant reduction of dinucleotide...

2023年11月25日 · In this study, we demonstrate that ME2 is highly expressed in human colorectal cancer (CRC) tissues, and that ME2 knockdown inhibits the proliferation of CRC cells. Furthermore, we reveal that...

2024年12月25日 · ME2 (Malic Enzyme 2) is a Protein Coding gene. Diseases associated with ME2 include Febrile Seizures, Familial, 8 and Opioid Dependence 1 . Among its related pathways are Metabolism of proteins and Regulation of pyruvate metabolism .

2-Methoxyestradiol (2-ME2)，具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物，是凋亡 (apoptosis) 诱导剂和血管生成 (angiogenesis) 抑制剂，具有有效的抗肿瘤活性。 2-Methoxyestradiol 也可破坏微管 (microtubules) 的稳定。 2-Methoxyestradiol 是一种有效的超氧化物歧化酶 (SOD) 抑制剂和活性氧生成剂，可诱导转化细胞系 HEK293、癌细胞系 U87 和 HeLa 的自噬 (autophagy)。 * Please select Quantity before adding items. • Theranostics. 2024 May …

2021年5月4日 · Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate binds ME2 with two complementary consequences. First, promoting the formation of ME2 dimers, which activate deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT).

2023年12月1日 · 导读：苹果酸酶2（malic enzyme 2, ME2）是一种定位于线粒体的代谢酶，催化苹果酸氧化脱羧生成丙酮酸，并伴随产生NADPH。 近年来，研究揭示ME2在肿瘤中异常高表达，是癌症治疗的潜在靶点，但其背后的活性调控机制尚未阐明。 近日，江南大学附属医院黄朝晖、李超群共同通讯在期刊《Cell Death & Differentiation》（IF:12.4）上发表题为“SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration”的研究 …

2021年5月4日 · Here, we report that the Krebs cycle intermediate fumarate links metabolism to mitobiogenesis through binding to malic enzyme 2 (ME2). Mechanistically, fumarate binds ME2 with two complementary consequences. First, promoting the formation of ME2 dimers, which activate deoxyuridine 5′-triphosphate nucleotidohydrolase (DUT).

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