CAN-2409 (aglatimagene besadenovec) is an adenoviral replication-defective engineered gene construct encoding the thymidine kinase gene derived from herpes simplex virus (HSV). CAN-2409 is injected directly into the tumor or target tissue.

CAN-2409 is a replication-defective adenovirus encoding the HSV-thymidine kinase gene, administered intratumorally in combination with a prodrug (valacyclovir or acyclovir). Cells transduced with CAN-2409 activate prodrug, resulting in immunogenic cell death and release of tumor neoantigens within the inflammatory tumor microenvironment.

2024年1月5日 · can-2409以前被称为基因介导的细胞毒性免疫疗法(gmci™)，是新型溶瘤病毒免疫疗法候选药物，它是一种复制缺陷型腺病毒，能将单纯疱疹病毒胸苷激酶(hsv-tk)基因传递给癌细胞。

2023年5月31日 · CAN-2409 is a replication-defective adenoviral construct encoding the herpes simplex virus thymidine kinase (HSV-tk) gene that is injected intratumorally followed by 2 weeks of prodrug (valacyclovir or acyclovir).

2021年4月22日 · CAN-2409, previously known as gene-mediated cytotoxic immunotherapy (GMCI™), Candel’s most advanced oncolytic viral immunotherapy candidate, is a replication-deficient adenovirus that delivers the herpes simplex …

2023年5月9日 · CAN-2409 has been shown to induce immunogenic cell death in glioblastoma and transform the immunologically “cold” into a “hot” tumor microenvironment. Although this is achieved by interfering with tumor cell DNA through incorporation of an antimetabolite -the HSV-tk metabolized prodrug ganciclovir, acyclovir or valacyclovir.

2021年9月7日 · CAN-2409, Candel’s most advanced oncolytic viral immunotherapy product candidate, is a replication-deficient adenoviral gene construct encoding the herpes simplex virus thymidine kinase (HSV-tk)...

2024年5月29日 · CAN-2409 is a replication-defective adenovirus encoding the HSV-tk gene. Transduced cells activate orally delivered valacyclovir, resulting in immunogenic cell death, and in situ immunization against the patient’s tumor antigens, eliciting a specific immune response against the injected tumor and uninjected metastases.

2024年12月11日 · CAN-2409 combined with valacyclovir and radiation therapy significantly improved DFS in prostate cancer patients, reducing recurrence or death risk by 30%. The investigational arm showed a 14.5%...

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