2003年4月2日 · DOI: 10.1001/jama.289.13.1681 Abstract Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are associated with skeletal muscle complaints, including clinically important myositis and rhabdomyolysis, mild serum creatine kinase (CK) elevations, myalgia with and without elevated CK levels, muscle weakness, muscle cramps, and ...

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We performed a literature review to provide a clinical summary of statin-associated myopathy and discuss possible mediating mechanisms. We also update the US Food and Drug Administration (FDA) reports on statin-associated rhabdomyolysis.

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2007年8月29日 · Thompson PD, Clarkson P, Karas RH: Statin-associated myopathy. JAMA 2003, 289: 1681–1690. Jacobson TA: Statin safety: lessons from new drug applications for marketed statins. Am J Cardiol 2006, 97 (8A): 44C–51C. Merck & Co: I: MECACOR (LOVASTATIN). In: Prescription Information. 2005.

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