GRPR/Extracellular Signal-Regulated Kinase and NPRA ... - PubMed
When human embryonic kidney 293T cells transfected with these receptors were exposed to their respective agonists, ERK was the most significantly activated intracellular signaling molecule. …
Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated …
2011年10月25日 · We detected MEK-dependent ETV3 phosphorylation in cells: Western blot analysis showed a MEK-dependent gel shift in ETV3 in DLD1 colon carcinoma cells and in …
CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop
2020年11月20日 · In parental 293T cells, expression of DUSP6 correlated well with the activity of ERK signaling, i.e., rise when ERK signaling is stimulated by FGF and drop when ERK …
ERK-dependent phosphorylation of the linker and substrate …
2019年9月26日 · ERK proteins coprecipitated with HSP70 were identified by SDS-PAGE and immunoblotting using an antibody against ERK. g Starved 293T cells containing GFP-ERK …
ERK Activation Globally Downregulates miRNAs through ... - Cell …
2016年11月14日 · In liver cancer, the ERK-mediated XPO5 suppression reduces miR-122, increases microtubule dynamics, and results in tumor development and drug resistance. …
BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing …
2010年11月19日 · FLAG-tagged Smad1 and Smad5 were overexpressed in 293T cells, and the effect of Erk activation or inhibition was observed (Fig. 5, A and B). Smad1 overexpression …
ERK upregulates DAPK catalytic activity. ( A ) Serum-starved 293T …
To demon- strate directly the induction of DAPK catalytic activity by ERK, 293T cells were cotransfected with Flag-DAPK and a constitutively active MEK1 mutant followed by serum …
ERK pathway phosphorylates and inhibits ZFP36L2. (A) 293T cells …
The serine residues identified as being phosphorylated downstream of ERK are shown in red. (D) 293T cells were transfected with Myc-tagged ZFP36L1 or ZFP36L2 and then treated with or …
ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK…
2014年9月2日 · These results indicate that ZFP36L1 is phosphorylated downstream of ERK. We then analyzed the ERK-dependent phosphorylation sites using an iTRAQ-based quantitative …
PI3K pathway is involved in ERK signaling cascade activation by ...
Methods: Phosphorylation levels of ERK and Akt were examined by Western blot in HEK293T cells expressing the human H2R, in the presence of H2R agonist and dominant negative …