Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs.

细胞色素p450 2c19酶（简称，cyp2c19），也称为s-美芬妥英羟化酶。 这种蛋白质是 细胞色素P450 多功能氧化酶系统的成员，参与 异型生物质 （如许多 质子泵 [ 1 ] 抑制剂和 镇痛剂 [ 2 ] ）的代谢。

2023年7月17日 · CYP2C19是 CYP450酶 第二亚家族中的重要成员，是人体重要的药物代谢酶，在肝脏中有很多表达。 能够催化体内包括氧化－还原作用，环氧化作用，N－脱羟基作用，O－脱羟基作用，S－氧化和羟基化作用的多种反应，也就是通过这诸多反应来影响药物对患者的药效和毒副反应的。 目前已证实的由CYP2C19参与代谢并明显影响其临床应用的药物多达几十种，包括 氯吡格雷 、抗癫痫药、抗抑郁药及 质子泵抑制剂 等。 CYP2C19酶的编码基因 …

The CYP450 enzyme CYP2C19 is at least partly involved in the metabolism of many drugs, but inhibitors of CYP2C19 will tend to have the greatest effect on drugs for which CYP2C19 is the primary pathway (eg, those with an asterisk in Table 1).

CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both, efficacy and safety issues for several commonly prescribed medications.

Enzymes produced from cytochrome P450 genes are involved in the formation and breakdown (metabolism) of various molecules and chemicals within cells. The CYP2C19 gene provides instructions for making an enzyme that is found primarily in liver cells in a cell structure called the endoplasmic reticulum, which is involved in protein processing and ...

The cytochrome P450 isoenzymes, mainly CYP2D6, CYP2C9, and CYP2C19 are responsible for the metabolism of the majority of psychotropic medications, including antipsychotics, antidepressants, and mood stabilizers.

2024年12月24日 · CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Drug Metabolism, Poor, Cyp2c19-Related and Major Depressive Disorder. Among its related pathways are Clomipramine Pathway, Pharmacokinetics and Metapathway biotransformation Phase I and II.

CYP2C19是CYP450酶第二亚家族中的重要成员，是人体重要的药物代谢酶，在肝脏中有很多表达。 CYP2C19基因座位于染色体区10q24.2上，都由9个外显子构成。 CYP2C19与CYP2C9有92%的序列同源性。

2018年1月30日 · CYP2C19 is an enzyme involved in the hydroxylation of the S form of an anti-epileptic agent mephenytoin, and also in the metabolism of a series of proton pump inhibitors such as omeprazole. The PM for CYP2C19 is found in about 20% of Japanese and about 3% of Caucasians [14].