1h-1h cosy，hsqc和hmbc属2d nmr，谱图表现形式与1d nmr不一样，由一个个点组成。 氢谱和碳谱只是描述单个原子信息，而2D NMR谱图可把单个原子信息联系起来，从而得知各个原子的相对位置关系。

The HSQC experiment is a highly sensitive 2D-NMR experiment and was first described in a 1 H— 15 N system, but is also applicable to other nuclei such as 1 H— 13 C and 1 H— 31 P. The basic scheme of this experiment involves the transfer of magnetization on the proton to the second nucleus, which may be 15 N, 13 C or 31 P, via an INEPT ...

Gained Information: The Heteronuclear Single Quantum Correlation (HSQC) NMR experiment is a proton-detected 2D experiment that shows you 1H / 13C one-bond connectivity. You will see your 1H spectrum as your direct F2 axis and your 13C spectrum as your indirect F1 axis.

2023年2月11日 · Heteronuclear Single Quantum Coherence. Hetereonuclear Single Quantum Coherence (HSQC) is used to determine the proton to carbon or heteroatom (often nitrogen) single bond correlations. It is also known as heteronuclear multiple quantum coherence (HMQC).

2024年5月22日 · 二维核磁 (Two-Dimensional NMR, 2D-NMR) 是一种强大的复杂有机化合物精确归属分析工具。 通过引入具有两个时间变量的核磁共振实验， 2D-NMR 将化学位移、偶合常数等重要参数展开在二维平面上，完美地解决了谱线的拥挤和重叠问题，同时还可以提供自旋核之间的 …

HSQC - Heteronuclear Multiple Quantum Correlation. This 2D experiment correlates the chemical shift of proton with the chemical shift of the directly bonded carbon. On the bottom axis is a proton spectrum and on the other is a carbon. Cross peaks give …

HMQC (Heteronuclear Multiple Quantum Correlation,异核多量子相关)：隶属于NMR（核磁共振）C-H COSY谱 图中的一种，HMQC给出的信息是直接相连的碳氢关系1JC-H，而不能解决碳与季碳相连的问题，或隔碳相连的问题。

Heteronuclear Single Quantum Coherence (HSQC) – Detecting One-Bond Couplings Purpose. HSQC (Heteronuclear Single Quantum Coherence) is a heteronuclear 2D NMR technique that correlates proton (1 H) chemical shifts with directly bonded heteronuclei (13 C, 15 N, etc.). This technique is particularly useful in protein NMR and complex organic ...

2010年7月2日 · 2D HSQC (Heteronuclear Single Quantum Coherence) experiment correlates chemical shifts of directly bound nuclei (i.e. two types of chemical nuclei). For example 1 H, 15 N-HSQC correlates chemical shifts within NH groups. For similar correlations over multiple bonds 2D HMBC experiment can be used.

HMQC, HSQC, HMBC and COSY are arguably the most useful 2D NMR experiments. HMQC and HSQC give correlation peaks for 1H atoms directly connected (through bond) to heteronuclear atoms and are the standards for determining 1H – 13C one bond correlations.